NCT05977439 · Medical University of South Carolina
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
What this study is about
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS).
View original scientific description
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation. The study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age 18-65 years
- Medically and psychiatrically healthy with no history of psychiatric or neurological disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential
Exclusion criteria
- Any current or past psychiatric diagnosis
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Substance use disorder (excluding nicotine or caffeine)
- Pregnancy or plans to become pregnant during study participation
- Inability to complete study procedures Studies 2, 3, and 4 (Participants with Depression) Inclusion Criteria:
- Age 18-65 years
- Current diagnosis of Major Depressive Disorder (MDD)
- Depression severity consistent with study criteria (e.g., HAM-D ≥ 17)
- No history of psychotic or bipolar disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential Exclusion Criteria:
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Substance use disorder (excluding nicotine or caffeine)
- Current participation in another interventional clinical trial
- Pregnancy or plans to become pregnant during study participation
- Any condition that would interfere with safe participation or completion of study procedures
Where
- Charleston, South Carolina
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 16, 2026 · Source of record for eligibility and locations