Charleston, SCNCT05977439Now EnrollingIRB Ready

Depression Clinical Trial in Charleston, SC

Access cutting-edge depression treatment through this clinical trial at a research site in Charleston. Study-provided care at no cost to qualified participants.

Sponsored by Medical University of South Carolina

Quick Self-Assessment

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Expert Care in Charleston

Access depression specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related depression treatment provided free

Apply for This Charleston Location

Check if you qualify for this depression clinical trial in Charleston, SC

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Charleston

    Convenient for SC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charleston site if eligible
  4. 4Begin participation

About This Depression Study in Charleston

In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation. The study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.

Sponsor: Medical University of South Carolina

Who Can Participate

Inclusion Criteria

Age 18-65 years
Medically and psychiatrically healthy with no history of psychiatric or neurological disorders
English-speaking
Capacity to provide informed consent
Willingness and ability to complete study procedures
Negative pregnancy test for participants of childbearing potential

Exclusion Criteria

Any current or past psychiatric diagnosis
Neurological disorders or history of central nervous system disease
History of seizure or epilepsy or use of medications that lower seizure threshold
Significant head injury or loss of consciousness
Implanted metal or contraindications to MRI or TMS
Substance use disorder (excluding nicotine or caffeine)
Pregnancy or plans to become pregnant during study participation
Inability to complete study procedures Studies 2, 3, and 4 (Participants with Depression) Inclusion Criteria:
Age 18-65 years
Current diagnosis of Major Depressive Disorder (MDD)
Depression severity consistent with study criteria (e.g., HAM-D ≥ 17)
No history of psychotic or bipolar disorders
English-speaking
Capacity to provide informed consent
Willingness and ability to complete study procedures
Negative pregnancy test for participants of childbearing potential Exclusion Criteria:
Neurological disorders or history of central nervous system disease
History of seizure or epilepsy or use of medications that lower seizure threshold
Significant head injury or loss of consciousness
Implanted metal or contraindications to MRI or TMS
Substance use disorder (excluding nicotine or caffeine)
Current participation in another interventional clinical trial
Pregnancy or plans to become pregnant during study participation
Any condition that would interfere with safe participation or completion of study procedures

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charleston?

Yes, this clinical trial (NCT05977439) has an active research site in Charleston, SC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depression Treatment Options in Charleston, SC

If you're searching for depression treatment options in Charleston, SC, this clinical trial (NCT05977439) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charleston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depression specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all depression clinical trials near you to find additional studies recruiting in your area.

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See all depression clinical trials recruiting in Charleston — not just this study.

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Secure · Expert Care · Charleston, SC