10 Colorectal Cancer Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Colorectal Cancer Studies in Chicago

NCT05732623Recruiting

Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germlin...

Chicago, IL2,300 participantsSan Raffaele University

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NCT05855200Recruiting

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective...

Chicago, ILPHASE3892 participantsGlaxoSmithKline

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NCT06898996Recruiting

FITting Non-invasive Tests in Lynch Syndrome Surveillance

The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy s...

Chicago, IL400 participantsUniversity of Chicago

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NCT06820463Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

CRC is the third most common type of cancer diagnosed worldwide with developed countries at highest risk. The purpose of this study is to assess adverse events and change in disease activity when teli...

Chicago, ILPHASE2390 participantsAbbVie

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NCT03998202Recruiting

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer....

Chicago, IL300 participantsWake Forest University Health Sciences

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NCT07023289Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide. The purpose of this study is to assess change in disease activity when telisotuzumab adizutecan is given alone comp...

Chicago, ILPHASE2140 participantsAbbVie

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NCT06937177Recruiting

Safely Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy

This is a randomized, double-blind, placebo-controlled study of B07, administered daily by subcutaneous (SC) injection, in up to 120 patients with newly diagnosed metastatic colorectal cancer. This st...

Chicago, ILPHASE2120 participantsEndevica Bio

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NCT06792695Recruiting

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

The main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer (CRC)....

Chicago, ILPHASE280 participantsAstraZeneca

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NCT06349590Recruiting

Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery

A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent. Su...

Chicago, ILPHASE180 participantsUniversity of Chicago

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NCT05943210Recruiting

The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer

This trial (molecular characterization trial) focuses on rectal cancer, a common cancer that is treated with radiotherapy (RT) as standard of care and represents a setting in which to study the effect...

Chicago, ILNA25 participantsWeill Medical College of Cornell University

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About Colorectal Cancer Clinical Trials in Chicago

Colorectal cancer starts in the colon or rectum and is the third most common cancer diagnosed in both men and women. Early detection through screening significantly improves outcomes. Treatments include surgery, chemotherapy, radiation, and targeted therapies.

There are currently 10 colorectal cancer clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 4,727 participants. Research is being sponsored by San Raffaele University, GlaxoSmithKline, University of Chicago and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Colorectal Cancer Clinical Trials in Chicago — FAQ

Are there colorectal cancer clinical trials in Chicago?

Yes, there are 10 colorectal cancer clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What colorectal cancer treatments are being tested?

The 10 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for colorectal cancer.

Data updated July 16, 2026 from ClinicalTrials.gov