6 Melanoma Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Melanoma Studies in Chicago

NCT05727904Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab al...

Chicago, ILPHASE3670 participantsIovance Biotherapeutics, Inc.

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NCT03567889Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients

The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of...

Chicago, ILPHASE3186 participantsPhilogen S.p.A.

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NCT07556380Recruiting

Sun Exposure and Activities After Skin Cancer: Optimization of mHealth Interventions

The purpose of this study is to evaluate 5 different smartphone administered sun protection interventions that aim to reduce unprotected sun exposure in melanoma survivors. Participants are asked to w...

Chicago, ILNA150 participantsNorthwestern University

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NCT06007690Recruiting

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melano...

Chicago, ILPHASE3100 participantsAura Biosciences

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NCT04572451Recruiting

Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors and Melanoma

Nivolumab (and other agents affecting the anti-programmed death-1 \[anti-PD-1\] pathway) have demonstrated anti-tumor activity in multiple tumor types. Combinations of immune-oncology (IO) agents with...

Chicago, ILPHASE150 participantsYana Najjar

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NCT06121180Recruiting

Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma

The goal of this clinical research study is to find out if Cemiplimab plus Ziv-Aflibercept is safe and effective in treating your condition of metastatic (spread to other parts of your body) uveal mel...

Chicago, ILPHASE232 participantsH. Lee Moffitt Cancer Center and Research Institute

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About Melanoma Clinical Trials in Chicago

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 6 melanoma clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 1,188 participants. Research is being sponsored by Iovance Biotherapeutics, Inc., Philogen S.p.A., Northwestern University and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in Chicago — FAQ

Are there melanoma clinical trials in Chicago?

Yes, there are 6 melanoma clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 6 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated July 16, 2026 from ClinicalTrials.gov