5 Substance Use Disorder Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Substance Use Disorder Studies in Chicago

NCT06651177Recruiting

Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

The primary objective of this research study is to evaluate the effect of tirzepatide, relative to placebo, as an adjunct to BUP on retention, substance use, and sleep outcomes in individuals with OUD...

Chicago, IL310 participantsT. John Winhusen, PhD

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NCT07216872Recruiting

Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)

The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment. This is a prospective, 6-...

Chicago, IL186 participantsBrainsway

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NCT05778734Recruiting

StuDy AimED at Increasing AlCohol AbsTinEnce

The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatm...

Chicago, IL104 participantsUniversity of Illinois at Chicago

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NCT06338280Recruiting

Remotely Observed Methadone Evaluation II

Methadone is an effective treatment for severe opioid use disorder (OUD), but access is limited due to the requirement of daily observed dosing by most opioid treatment programs (OTPs). Sonara Health ...

Chicago, IL100 participantsSonara Health

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NCT06139224Recruiting

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART). Our...

Chicago, IL40 participantsRush University Medical Center

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About Substance Use Disorder Clinical Trials in Chicago

Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.

There are currently 5 substance use disorder clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 740 participants. Research is being sponsored by T. John Winhusen, PhD, Brainsway, University of Illinois at Chicago and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Substance Use Disorder Clinical Trials in Chicago — FAQ

Are there substance use disorder clinical trials in Chicago?

Yes, there are 5 substance use disorder clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What substance use disorder treatments are being tested?

The 5 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for substance use disorder.

Data updated July 13, 2026 from ClinicalTrials.gov