13 Breast Cancer Clinical Trials in Durham, NC (2026)

Q: How do I join a clinical trial in Durham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Durham research site will contact you.

Recruiting Breast Cancer Studies in Durham

NCT06512350Recruiting

Identifying Patterns in the Breath of Individuals With Breast Cancer

Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be leveraged to facilitate breast cancer de...

Durham, NC5,175 participantsBreathe BioMedical Inc

View Study Details

NCT07140172Recruiting

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Li...

Durham, NCNA1,060 participantsUniversity Hospital, Basel, Switzerland

View Study Details

NCT06275126Recruiting

Optimizing Surgical Decisions in Young Adults With Breast Cancer

The goal of this study is to understand and improve the breast surgical decision-making process for young women newly diagnosed with breast cancer. As part of this study, the investigators will evalua...

Durham, NCNA800 participantsWeill Medical College of Cornell University

View Study Details

NCT06896474Recruiting

SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

Investigators aim to conduct a type 1 hybrid effectiveness-implementation surgeon-level cluster randomized clinical trial (RCT) of a multi-level intervention, a shared decision making training for sur...

Durham, NCNA402 participantsBeth Israel Deaconess Medical Center

View Study Details

NCT06795529Recruiting

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not a...

Durham, NCNA400 participantsMassachusetts General Hospital

View Study Details

NCT06555588Recruiting

Engage Psychosocial Intervention for Cancer Symptoms

The goal of this clinical trial is to test the efficacy a new psychosocial symptom management intervention called ENGAGE for patients with Stage IV breast, prostate, lung, or colorectal cancer. Partic...

Durham, NCNA190 participantsDuke University

View Study Details

NCT07300995Recruiting

Behavioral Pain Intervention for Older Cancer Patients

This randomized controlled trial examines a 1-session, telehealth pain coping skills training (PCST) protocol with five 15-minute maintenance calls (Brief PCST-Community) adapted for women with breast...

Durham, NCNA168 participantsDuke University

View Study Details

NCT05846789Recruiting

SOC Chemotherapy +/- Tocilizumab for Triple Negative and ER-low Breast Cancers

This is a randomized Phase II study of standard of care (SOC) chemotherapy monotherapy vs. SOC chemotherapy combined with tocilizumab in in Black and non-Black patients with metastatic triple negative...

Durham, NCPHASE2168 participantsKathy Miller

View Study Details

NCT05735080Recruiting

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Incyclix Bio (Incyclix) is developing INX-315 as an oral, small molecule inhibitor of cyclin dependent kinase 2 (CDK2) for the treatment of human cancers. This first-in-human study is designed to eval...

Durham, NCPHASE1150 participantsIncyclix Bio

View Study Details

NCT07335354Recruiting

A Study of a Decision Tool for People Considering Breast Reconstruction Surgery

The purpose of this study is to find out whether it is practical (feasible) to do a larger study looking at the effectiveness of the Breast Reconstruction Decision Aid Tool (RECONJOINT) for breast rec...

Durham, NCNA131 participantsMemorial Sloan Kettering Cancer Center

View Study Details

NCT05309655Recruiting

Cardiac Outcomes With Near-Complete Estrogen Deprivation

The purpose of this research study is to understand what effect near complete estrogen deprivation (NCED) therapy has on the heart in breast cancer patients. Investigators want to understand if NCED c...

Durham, NCNA90 participantsDuke University

View Study Details

NCT06176261Recruiting

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

The purpose of this study is to test the safety and effectiveness of the study drug datopotamab deruxtecan in participants with metastatic breast cancer that has spread to the brain. The name of the ...

Durham, NCPHASE258 participantsSarah Sammons, MD

View Study Details

NCT05974150Recruiting

Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring

The goal of this study is to create a data set to add to Carevive's registry from real world clinical and patient reported data collected using an electronic care planning system (CPS) with remote sym...

Durham, NC25 participantsCarevive Systems, Inc.

View Study Details

About Breast Cancer Clinical Trials in Durham

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 13 breast cancer clinical trials recruiting participants in Durham, NC. These studies are seeking a combined 8,817 participants. Research is being sponsored by Breathe BioMedical Inc, University Hospital, Basel, Switzerland, Weill Medical College of Cornell University and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Durham — FAQ

Are there breast cancer clinical trials in Durham?

Yes, there are 13 breast cancer clinical trials currently recruiting in Durham, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Durham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Durham research site will contact you about next steps.

Are clinical trials in Durham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Durham studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 13 active trials in Durham are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 18, 2026 from ClinicalTrials.gov