11 Breast Cancer Clinical Trials in Fountain Valley, CA (2026)

Q: How do I join a clinical trial in Fountain Valley?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Fountain Valley research site will contact you.

Recruiting Breast Cancer Studies in Fountain Valley

NCT05952557Recruiting

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high ...

Fountain Valley, CAPHASE35,500 participantsAstraZeneca

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NCT05774951Recruiting

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk f...

Fountain Valley, CAPHASE34,300 participantsAstraZeneca

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NCT06393374Recruiting

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (MK-2870) in combination with pembrolizumab compared to treatment of physician's choice (TP...

Fountain Valley, CAPHASE31,530 participantsMerck Sharp & Dohme LLC

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NCT05633654Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatmen...

Fountain Valley, CAPHASE31,514 participantsGilead Sciences

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NCT07492641Recruiting

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

The purpose of this study is to investigate the efficacy and safety of BGB-43395 in combination with letrozole compared with investigator's choice of cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) in...

Fountain Valley, CAPHASE31,056 participantsBeOne Medicines

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NCT04862663Recruiting

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Fact...

Fountain Valley, CAPHASE3895 participantsAstraZeneca

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NCT06016738Recruiting

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whos...

Fountain Valley, CAPHASE3510 participantsOlema Pharmaceuticals, Inc.

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NCT06380751Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positiv...

Fountain Valley, CAPHASE3500 participantsAstraZeneca

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NCT06072612Recruiting

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor \[Retifanlimab\], versus Treatment of Patients'/Physi...

Fountain Valley, CAPHASE3404 participantsBriaCell Therapeutics Corporation

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NCT06369285Recruiting

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

PUMA-ALI-1201 is a randomized, dose optimization, multicenter, Phase 2 study of alisertib administered in combination with endocrine therapy in participants with pathology-confirmed HR-positive/HER2-n...

Fountain Valley, CAPHASE2150 participantsPuma Biotechnology, Inc.

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NCT06966453Recruiting

A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

The purpose of this clinical study is to learn about the safety and effects of the study medicine (called disitamab vedotin) for the possible treatment of people with breast cancer that is hard to tre...

Fountain Valley, CAPHASE1100 participantsPfizer

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About Breast Cancer Clinical Trials in Fountain Valley

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 11 breast cancer clinical trials recruiting participants in Fountain Valley, CA. These studies are seeking a combined 16,459 participants. Research is being sponsored by AstraZeneca, Merck Sharp & Dohme LLC, Gilead Sciences and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Fountain Valley — FAQ

Are there breast cancer clinical trials in Fountain Valley?

Yes, there are 11 breast cancer clinical trials currently recruiting in Fountain Valley, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Fountain Valley?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Fountain Valley research site will contact you about next steps.

Are clinical trials in Fountain Valley free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Fountain Valley studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 11 active trials in Fountain Valley are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 18, 2026 from ClinicalTrials.gov