29 Breast Cancer Clinical Trials in Jacksonville, NC (2026)

Q: How do I join a clinical trial in Jacksonville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Jacksonville research site will contact you.

Recruiting Breast Cancer Studies in Jacksonville

NCT06512350Recruiting

Identifying Patterns in the Breath of Individuals With Breast Cancer

Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be leveraged to facilitate breast cancer de...

Jacksonville, NC5,175 participantsBreathe BioMedical Inc

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NCT07207564Recruiting

Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk

The purpose of this research is to better understand how benign breast diseases might lead to breast cancer, focusing on genetic factors and including a diverse range of participants to improve future...

Jacksonville, NC4,500 participantsMayo Clinic

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NCT04475640Recruiting

Cancer Genetic Testing in Ethnic Populations

This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may help identify cancer genes and other perso...

Jacksonville, NCNA1,800 participantsMayo Clinic

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NCT00477100Recruiting

Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer

This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer. Collecting medical data and storing sampl...

Jacksonville, NC1,200 participantsM.D. Anderson Cancer Center

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NCT06380751Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positiv...

Jacksonville, NCPHASE3788 participantsAstraZeneca

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NCT07076485Recruiting

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning....

Jacksonville, NCPHASE2768 participantsM.D. Anderson Cancer Center

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NCT05696626Recruiting

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

The goal of this clinical trial is to assess the efficacy, safety and tolerability of the combination of lasofoxifene and abemaciclib compared to fulvestrant and abemaciclib for the treatment of pre- ...

Jacksonville, NCPHASE3600 participantsSermonix Pharmaceuticals Inc.

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NCT05377996Recruiting

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

A Study of Emi-Le in Participants with Solid Tumors...

Jacksonville, NCPHASE1360 participantsDay One Biopharmaceuticals, Inc.

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NCT06349642Recruiting

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

This study is being done to collect tissue samples to test how accurately a tumor response platform, Elephas, can predict clinical response across multiple types of immunotherapies, chemoimmunotherapy...

Jacksonville, NC324 participantsMayo Clinic

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NCT05856773Recruiting

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

The purpose of this research study is to learn more about the effects of using proton radiation therapy delivered over a shorter course of treatment (3 weeks) compared with a longer, standard course o...

Jacksonville, NCPHASE3276 participantsProton Collaborative Group

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NCT05307705Recruiting

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-783. LOXO-783 may be used to treat breast cancer and other solid tumors that have a change in ...

Jacksonville, NCPHASE1260 participantsEli Lilly and Company

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NCT06369285Recruiting

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

PUMA-ALI-1201 is a randomized, dose optimization, multicenter, Phase 2 study of alisertib administered in combination with endocrine therapy in participants with pathology-confirmed HR-positive/HER2-n...

Jacksonville, NCPHASE2225 participantsPuma Biotechnology, Inc.

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NCT05507879Recruiting

TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

This study examines TRPC6 in predicting and preventing chemotherapy related cardiac toxicity and heart failure in patients with breast cancer. Cardiac toxicity, changes in heart function is a well-rec...

Jacksonville, NC200 participantsMayo Clinic

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NCT06783179Recruiting

Postoperative Outcomes and Patient Satisfaction With Mayo Clinic Florida Care Hotel After Mastectomy and Tissue Expander Placement

This study evaluates the postoperative outcomes of patients who are admitted to the Mayo Clinic Florida Care Hotel after mastectomy and tissue expander placement. At Mayo Clinic Florida, patients rece...

Jacksonville, NC150 participantsMayo Clinic

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NCT05269381Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

This phase I/II trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spre...

Jacksonville, NCPHASE1138 participantsMayo Clinic

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NCT07007559Recruiting

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

The Substudy Protocol ASPEN-09-03 is a Phase 2, single-arm, multicenter study evaluating the efficacy, safety, and tolerability of evorpacept in combination with trastuzumab and chemotherapy in partic...

Jacksonville, NCPHASE2120 participantsALX Oncology Inc.

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NCT06831838Recruiting

A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors

The purpose of this research is to evaluate the effectiveness of a multidisciplinary pain management program for AIMSS in reducing pain, subjective cognitive complaints, psychological distress, and im...

Jacksonville, NCNA116 participantsMayo Clinic

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NCT06388122Recruiting

DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients

This study is being done to determine if there is a pattern associated with response to endocrine therapy alone and in combination with CDK4/6 inhibitor used for hormone receptor positive HER2 negativ...

Jacksonville, NC100 participantsMayo Clinic

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NCT07405801Recruiting

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

A study to evaluate the efficacy and safety of triplet combination of inavolisib plus ribociclib and fulvestrant versus placebo plus ribociclib and fulvestrant in the first-line setting in participant...

Jacksonville, NCPHASE280 participantsHoffmann-La Roche

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NCT07368998Recruiting

To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

The purpose of this study is to evaluate the efficacy and safety of inavolisib in combination with fulvestrant compared with inavolisib in combination with fulvestrant in participants with PIK3CA-muta...

Jacksonville, NCPHASE280 participantsHoffmann-La Roche

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NCT06590857Recruiting

Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.

Phase 1b/2 open-label trial of 225Ac-DOTATATE (RYZ101) in subjects with ER+, HER2-negative unresectable or metastatic breast cancer expressing SSTRs....

Jacksonville, NCPHASE164 participantsRayzeBio, Inc.

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NCT07311993Recruiting

Phase 1 Study of CLR 125 in Triple Negative Breast Cancer

The goal of this clinical trial is to evaluate the safety and efficacy of 3 different dose levels of CLR 125 in patients with advanced triple negative breast cancer. The main questions the study aims ...

Jacksonville, NCPHASE160 participantsCellectar Biosciences, Inc.

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NCT05501704Recruiting

ETHAN - ET for Male BC

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male...

Jacksonville, NCPHASE260 participantsJose Pablo Leone

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NCT05557877Recruiting

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) women planning to have a breast biopsy. Chronic inflammation may increase the ris...

Jacksonville, NCPHASE260 participantsMayo Clinic

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NCT06153836Recruiting

Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction

This phase II trial tests the willingness of patients undergoing nipple sparing mastectomy (NSM) to enroll in a randomized study of NSM with or without neurotization of the nipple areolar complex (NAC...

Jacksonville, NCPHASE245 participantsMayo Clinic

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NCT07044310Recruiting

5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

This phase II trial tests how well a probiotic, WBF-038, works in preventing bone loss in patients with early-stage hormone receptor-positive breast cancer who are starting treatment with aromatase in...

Jacksonville, NCPHASE238 participantsMayo Clinic

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NCT06401889Recruiting

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

This study evaluates changes in skin quality and self-esteem among breast cancer patients who are initiating aromatase inhibitor therapy....

Jacksonville, NC35 participantsMayo Clinic

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NCT07192432Recruiting

Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

This is a Phase 1/2, first-in-human, open-label, dose-escalating and expansion trial designed to assess the safety and efficacy of VNX-202 in patients with HER2 positive cancers....

Jacksonville, NCPHASE127 participantsVironexis Biotherapeutics Inc.

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NCT05746325Recruiting

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

This clinical trial evaluates the safety and feasibility of tumor treating fields (TTF) in the treatment of spinal leptomeningeal disease in patients with breast or lung cancer that has spread from wh...

Jacksonville, NCNA5 participantsMayo Clinic

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About Breast Cancer Clinical Trials in Jacksonville

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 29 breast cancer clinical trials recruiting participants in Jacksonville, NC. These studies are seeking a combined 17,654 participants. Research is being sponsored by Breathe BioMedical Inc, Mayo Clinic, M.D. Anderson Cancer Center and 12 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Jacksonville — FAQ

Are there breast cancer clinical trials in Jacksonville?

Yes, there are 29 breast cancer clinical trials currently recruiting in Jacksonville, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Jacksonville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Jacksonville research site will contact you about next steps.

Are clinical trials in Jacksonville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Jacksonville studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 29 active trials in Jacksonville are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated October 14, 2026 from ClinicalTrials.gov