8 Ulcerative Colitis Clinical Trials in Lancaster, PA (2026)

Q: How do I join a clinical trial in Lancaster?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Lancaster research site will contact you.

Recruiting Ulcerative Colitis Studies in Lancaster

NCT07196748Recruiting

A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this protocol is to evaluate the efficacy (how well it works), safety and tolerability of oral icotrokinra as therapy in adult and adolescent participants with moderately to severely ac...

Lancaster, PAPHASE3882 participantsJanssen Research & Development, LLC

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NCT07012395Recruiting

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficac...

Lancaster, PAPHASE2645 participantsSpyre Therapeutics, Inc.

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NCT06588855Recruiting

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

This Phase III, multicenter, double-blind, placebo-controlled study will evaluate the efficacy and safety of induction therapy with Afimkibart (RO7790121) compared with placebo in participants with mo...

Lancaster, PAPHASE3350 participantsHoffmann-La Roche

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NCT07186101Recruiting

LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely activ...

Lancaster, PAPHASE2252 participantsEli Lilly and Company

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NCT06979336Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventiona...

Lancaster, PAPHASE2224 participantsGenentech, Inc.

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NCT06029972Recruiting

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

The goal of this study is to learn if tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with moderate to severe ulcerative colitis. The study will comp...

Lancaster, PAPHASE2176 participantsGilead Sciences

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NCT06598943Recruiting

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC)....

Lancaster, PAPHASE2140 participantsEli Lilly and Company

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NCT06975722Recruiting

A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Ulcerative Colitis. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compare...

Lancaster, PAPHASE299 participantsSanofi

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About Ulcerative Colitis Clinical Trials in Lancaster

Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation and ulcers in the innermost lining of the colon and rectum. It typically presents with bloody diarrhea, abdominal pain, and urgency. Treatment includes aminosalicylates, corticosteroids, immunosuppressants, and biologics.

There are currently 8 ulcerative colitis clinical trials recruiting participants in Lancaster, PA. These studies are seeking a combined 2,768 participants. Research is being sponsored by Janssen Research & Development, LLC, Spyre Therapeutics, Inc., Hoffmann-La Roche and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Ulcerative Colitis Clinical Trials in Lancaster — FAQ

Are there ulcerative colitis clinical trials in Lancaster?

Yes, there are 8 ulcerative colitis clinical trials currently recruiting in Lancaster, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Lancaster?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Lancaster research site will contact you about next steps.

Are clinical trials in Lancaster free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Lancaster studies also compensate for your time and travel.

What ulcerative colitis treatments are being tested?

The 8 active trials in Lancaster are testing new therapies including novel drugs, biologics, and treatment approaches for ulcerative colitis.

Data updated July 19, 2026 from ClinicalTrials.gov