Los Angeles, CA7 Active Studies

Depression Clinical Trials in Los Angeles, CA

Find 7 actively recruiting depression clinical trials in Los Angeles, CA. Connect with local research sites and explore new treatment options.

7
Active Trials
6
Sponsors
2,143
Enrolling

Recruiting Depression Studies in Los Angeles

RecruitingLos Angeles, CANCT05711940

Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)...

568 participants
COMPASS Pathways
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RecruitingLos Angeles, CANCT06775379

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...

450 participants
Xenon Pharmaceuticals Inc.
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RecruitingLos Angeles, CANCT05922878

Study of ALTO-300 in MDD

The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics....

321 participants
Alto Neuroscience
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RecruitingLos Angeles, CANCT06308653

Psilocybin for Major Depressive Disorder (MDD)

Approximately 240 eligible adult participants (≥18 years old) who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) criteria for Major Depressive Disorder (MDD) will be enrolled. P...

240 participants
Usona Institute
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RecruitingLos Angeles, CANCT06963021

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

200 participants
Neurocrine Biosciences
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RecruitingLos Angeles, CANCT06656416

ALTO-100 in Bipolar Disorder With Depression (BD-D)

The purpose of this study is to assess antidepressant efficacy differences between ALTO-100 and placebo during the Double-Blind period in patients with bipolar disorder I or II with current major depr...

200 participants
Alto Neuroscience
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RecruitingLos Angeles, CANCT06547489

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are: Does GATE-251 r...

164 participants
Syndeio Biosciences, Inc
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About Depression Clinical Trials in Los Angeles

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 7 depression clinical trials recruiting participants in Los Angeles, CA. These studies are seeking a combined 2,143 participants. Research is being sponsored by COMPASS Pathways, Xenon Pharmaceuticals Inc., Alto Neuroscience and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Los Angeles — FAQ

Are there depression clinical trials in Los Angeles?

Yes, there are 7 depression clinical trials currently recruiting in Los Angeles, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Los Angeles?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Los Angeles research site will contact you about next steps.

Are clinical trials in Los Angeles free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Los Angeles studies also compensate for your time and travel.

What depression treatments are being tested?

The 7 active trials in Los Angeles are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated March 2, 2026 from ClinicalTrials.gov