28 Depression Clinical Trials in New York, NY (2026)

Q: How do I join a clinical trial in New York?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you.

Recruiting Depression Studies in New York

NCT05800925Recruiting

Triage Survey for Psychiatry Research Eligibility

TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials....

New York, NY20,000 participantsAdams Clinical

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NCT06981598Recruiting

Prevention of Psychological Health Problems Via Integrated Operational Support

Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit ...

New York, NYNA5,586 participantsNew York University

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NCT04982757Recruiting

Accelerated TMS for Depression and OCD

Repetitive transcranial magnetic stimulation (rTMS) is a FDA-approved treatment for depression and Obsessive Compulsive Disorder (OCD). The goal of the study is to learn how to optimize the treatment ...

New York, NYNA500 participantsWeill Medical College of Cornell University

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NCT04041479Recruiting

Biomarker-guided rTMS for Treatment Resistant Depression

Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research ...

New York, NYPHASE3348 participantsWeill Medical College of Cornell University

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NCT04940585Recruiting

ROSE in Sunset Park

The purpose of this study is to learn more about pregnant women's' experience with Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) and to evaluate the effectiveness of the ROSE progr...

New York, NYNA308 participantsNYU Langone Health

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NCT04621877Recruiting

Lay-Delivered Behavioral Activation in Senior Centers

In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified Behavioral Activation to be...

New York, NYNA288 participantsUniversity of Washington

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NCT05466851Recruiting

An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression

This research study is studying how thoughts, feelings, surroundings, and individual biology may contribute to why and how people experience anxiety or depression. We are trying to find out the wide ...

New York, NY200 participantsSingula Institute

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NCT07390331Recruiting

A Patient Activation Approach to Implementing Depression Treatment in Cardiac Patients

This study, which is being conducted as part of a Quality Improvement (QI) Initiative at Columbia University Irving Medical Center, will test whether delivering the iHeart DepCare tool increases real ...

New York, NYNA200 participantsColumbia University

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NCT07210255Recruiting

SAINT in Postpartum Depression (PPD)

This study is a large, multi-site clinical trial testing whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), a fast-acting form of repetitive transcranial magnetic stimulation (r...

New York, NYNA192 participantsMagnus Medical

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NCT06039930Recruiting

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

The purpose of this randomized trial is to conduct a fully powered effectiveness trial of video-delivered PROTECT (Tele-PROTECT) compared to a video-delivered depression education (DepEd) control cond...

New York, NYNA140 participantsWeill Medical College of Cornell University

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NCT05925322Recruiting

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduc...

New York, NYNA128 participantsWeill Medical College of Cornell University

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NCT06213324Recruiting

Neural Circuit Effects of Ketamine in Depression

This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketami...

New York, NYPHASE4120 participantsIcahn School of Medicine at Mount Sinai

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NCT05573074Recruiting

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like li...

New York, NYNA120 participantsNYU Langone Health

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NCT07610473Recruiting

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

In this study, researchers will learn more about a study drug called DT-101 in participants with Major Depressive Disorder (MDD), a form of depression. The goal of this clinical trial is to learn if D...

New York, NYPHASE2118 participantsDraig Therapeutics Ltd

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NCT06455527Recruiting

Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)

This technology development project will be informed and guided by initial data collection of human subject data. For this purpose, the investigators will recruit n=100 people with mild to moderate de...

New York, NYNA100 participantsNYU Langone Health

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NCT05617495Recruiting

Mindfulness-Based fMRI Neurofeedback for Depression

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promisin...

New York, NYNA90 participantsColumbia University

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NCT06938841Recruiting

Maintenance rTMS for Depression (Maitr-De)

Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a ...

New York, NYNA75 participantsUniversity of California, San Diego

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NCT06559826Recruiting

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

The proposed study is a single-site, randomized, controlled clinical trial (RCT) comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of ketamine administered in a medi...

New York, NYPHASE270 participantsIcahn School of Medicine at Mount Sinai

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NCT07493317Recruiting

Neutralizing Interleukin (IL)-6

The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (...

New York, NYPHASE260 participantsIcahn School of Medicine at Mount Sinai

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NCT06592833Recruiting

Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder

This is an interventional, parallel arm assignment treatment study in individuals with Major Depressive Disorder (MDD). Each individual will be treated with a single dose of pimavanserin or placebo pl...

New York, NYPHASE260 participantsIcahn School of Medicine at Mount Sinai

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NCT05585164Recruiting

Engage & Connect: A Psychotherapy for Postpartum Depression

This randomized controlled trial compares a novel psychotherapy, Engage \& Connect, with a Symptom Review and Psychoeducation intervention, tailored to reduce postpartum depression. The study includes...

New York, NYNA60 participantsWeill Medical College of Cornell University

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NCT07111390Recruiting

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE). Participants will be randomi...

New York, NYNA40 participantsNYU Langone Health

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NCT07572526Recruiting

tDCS: Sleep to Mood in Depression (S2M-D)

The purpose of this study is to determine whether changes in sleep consolidation occur during home-based transcranial direct current stimulation (tDCS) in adults with moderate depression and whether t...

New York, NYNA35 participantsNYU Langone Health

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NCT07139834Recruiting

Pattern Separation in Major Depressive Disorder

This study seeks to examine the effects of treatment with a selective serotonin reuptake inhibitor (SSRI), escitalopram, a first-line treatment for depression, in combination with placebo or with exte...

New York, NYPHASE130 participantsJeffrey Miller

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NCT07218055Recruiting

Assessment of Music Experiences in Navigating Depression Part 2

This study is again looking at the use of music and music therapy experiences in navigating depression. The researchers will provide 11 sessions of music therapy and half will be followed by recitals ...

New York, NYNA20 participantsIcahn School of Medicine at Mount Sinai

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NCT05773755Recruiting

DBS for TRD With the Medtronic Percept PC

Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the ...

New York, NYNA20 participantsHelen Mayberg, MD

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NCT05757791Recruiting

Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD)

The primary purpose of this study is to determine whether empagliflozin, a medication in a class known as sodium-glucose cotransporter-2 inhibitors (SGLT2) inhibitors, may reduce symptoms of depressio...

New York, NYPHASE216 participantsNYU Langone Health

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NCT05239780Recruiting

Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients

Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder. These have been applied mos...

New York, NYNA10 participantsIcahn School of Medicine at Mount Sinai

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About Depression Clinical Trials in New York

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 28 depression clinical trials recruiting participants in New York, NY. These studies are seeking a combined 28,934 participants. Research is being sponsored by Adams Clinical, New York University, Weill Medical College of Cornell University and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in New York — FAQ

Are there depression clinical trials in New York?

Yes, there are 28 depression clinical trials currently recruiting in New York, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in New York?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you about next steps.

Are clinical trials in New York free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many New York studies also compensate for your time and travel.

What depression treatments are being tested?

The 28 active trials in New York are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 21, 2026 from ClinicalTrials.gov