13 Melanoma Clinical Trials in New York, NY (2026)

Q: How do I join a clinical trial in New York?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you.

Recruiting Melanoma Studies in New York

NCT07222995Recruiting

Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in FQHCs

The purpose of this study is to examine how different messages about risk of skin cancer can impact the uptake of skin cancer prevention activities....

New York, NYNA2,900 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT03947385Recruiting

Study of IDE196 in Patients with Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

This is a Phase 1/2, multi-center, open-label basket study designed to evaluate the safety and anti-tumor activity of IDE196 in patients with solid tumors harboring GNAQ or GNA11 (GNAQ/11) mutations o...

New York, NYPHASE1336 participantsIDEAYA Biosciences

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NCT03567889Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients

The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of...

New York, NYPHASE3186 participantsPhilogen S.p.A.

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NCT06284590Recruiting

Study of the Efficacy of Intratumoral L19IL2 or L19TNF or L19IL2/L19TNF, in Combination with Pembrolizumab, in Unresectable Melanoma Patients

The trial aims to evaluate the efficacy of single agent L19IL2, single agent L19TNF, and combination L19IL2+L19TNF given concurrently with anti-PD1 therapy compared to historical control of anti-PD-1 ...

New York, NYPHASE2162 participantsPhilogen S.p.A.

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NCT05428007Recruiting

Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma

The study will evaluate how safe the study drug is, how well you tolerate it, and how it works in the body and the disease's response to the drug. The study drug being tested is sarilumab, when given ...

New York, NYPHASE2105 participantsNYU Langone Health

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NCT07504796Recruiting

ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab

The purpose of this study is to investigate the use of ctDNA measurements to guide first-lien therapy choice for patients with advanced or metastatic melanoma. Primary endpoints include progression-fr...

New York, NYPHASE490 participantsNYU Langone Health

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NCT06594991Recruiting

A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma

The purpose of this study is to test whether the combination of fianlimab, cemiplimab, and ipilimumab is a safe and effective treatment that causes few or mild side effects for locally advanced or met...

New York, NYPHASE288 participantsMemorial Sloan Kettering Cancer Center

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NCT05839912Recruiting

Excision of Lymph Node Trial (EXCILYNT) (Mel69)

The purpose of this study is to find out if removing only the cancerous lymph node (known as a lymph node excision) is effective at preventing cancer from coming back in the same area of the lymph nod...

New York, NYNA66 participantsCraig L Slingluff, Jr

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NCT05361174Recruiting

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC)....

New York, NYPHASE153 participantsIovance Biotherapeutics, Inc.

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NCT05607095Recruiting

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

This is an open label study evaluating lifileucel (LN-144) in patients with metastatic uveal melanoma....

New York, NYPHASE140 participantsMemorial Sloan Kettering Cancer Center

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NCT07584226Recruiting

A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

This is a Phase 1 first-in-human, open-label multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of RLY-8161, a...

New York, NYPHASE135 participantsRelay Therapeutics, Inc.

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NCT05384496Recruiting

Axitinib and Nivolumab for the Treatment of Mucosal Melanoma

The researchers are doing this study to find out whether the combination of axitinib and nivolumab is an effective and safe treatment for people with advanced or metastatic mucosal melanoma that has n...

New York, NYPHASE220 participantsMemorial Sloan Kettering Cancer Center

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NCT06946225Recruiting

ACTengine® IMA203 Combined With mRNA-4203

This purpose of this clinical trial is to evaluate the safety, tolerability and anti-tumor activity of IMA203 in combination with different doses of mRNA-4203. The trial includes participants with pre...

New York, NYPHASE115 participantsImmatics US, Inc.

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About Melanoma Clinical Trials in New York

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 13 melanoma clinical trials recruiting participants in New York, NY. These studies are seeking a combined 4,096 participants. Research is being sponsored by H. Lee Moffitt Cancer Center and Research Institute, IDEAYA Biosciences, Philogen S.p.A. and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in New York — FAQ

Are there melanoma clinical trials in New York?

Yes, there are 13 melanoma clinical trials currently recruiting in New York, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in New York?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you about next steps.

Are clinical trials in New York free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many New York studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 13 active trials in New York are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated July 18, 2026 from ClinicalTrials.gov