51 Ankylosing Spondylitis Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Ankylosing Spondylitis Studies in Philadelphia

NCT04604418Recruiting

Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures

The incidence of moderate to severe congenital heart disease (CHD) in the United States is estimated to be 6 per 1000 live-born full term infants. Recent advances in pediatric cardiology, surgery and ...

Philadelphia, PA10,000 participantsBoston Children's Hospital

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NCT01577251Recruiting

The Radiation Oncology Registry and Biosample Repository

The goal of this study is to establish a registry and biosample repository (defined as blood, urine, and tumor specimens) in patients with a cancer and/or benign tumor diagnosis undergoing radiotherap...

Philadelphia, PA8,000 participantsAbramson Cancer Center at Penn Medicine

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NCT06888388Recruiting

Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple ar...

Philadelphia, PA4,700 participantsSir Mortimer B. Davis - Jewish General Hospital

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NCT00345930Recruiting

DILIN - Prospective Study

The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine. Recently ...

Philadelphia, PA4,000 participantsDuke University

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NCT05002543Recruiting

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

MANTRA is a prospective, multiple-arm, multi-center, global, post-market clinical follow-up study. The main objective is to monitor ongoing safety and performance of the CORCYM devices and accessories...

Philadelphia, PA2,150 participantsCorcym S.r.l

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NCT05754658Recruiting

African Cancer Genome: GMD

The goal of this study is to develop a comprehensive characterization of genetic and molecular drivers of breast and prostate cancer in individuals of African ancestry. The study is conducted by the A...

Philadelphia, PA1,500 participantsFox Chase Cancer Center

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NCT00327860Recruiting

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the Eunice Kennedy Shriver Nat...

Philadelphia, PA1,300 participantsJohns Hopkins Bloomberg School of Public Health

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NCT06970977Recruiting

CRS Questionnaire Validation Project

The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perc...

Philadelphia, PA1,000 participantsThe European Forum for Research and Education in Allergy and Airway Diseases

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NCT05733832Recruiting

A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease

Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitio...

Philadelphia, PANA1,000 participantsIndiana University

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NCT04959097Recruiting

Retinoblastoma Patient Clinical Database and Tissue Repository

Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been s...

Philadelphia, PA800 participantsChildren's Hospital Los Angeles

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NCT06385886Recruiting

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

The goal of this observational study is to help us understand more about the best ways to help individuals living with Sickle Cell Disease (SCD) get the best care. The main question it aims to answer ...

Philadelphia, PA500 participantsRTI International

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NCT06772493Recruiting

ViewFlex X ICE First-in-Human Study

This prospective, acute, first-in-human, non-significant risk study is intended to evaluate a modified version of the ViewFlex X ICE Catheter, Sensor Enabled (ViewFlex X SE) and ViewMate Multi Ultraso...

Philadelphia, PA500 participantsAbbott Medical Devices

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NCT06121011Recruiting

A Global Prospective Observational Registry of Patients With Pompe Disease

This is a global, multicenter, prospective, observational registry of patients with Pompe disease, including those with late-onset pompe disease (LOPD) and infantile-onset pompe disease (IOPD). Both u...

Philadelphia, PA500 participantsAmicus Therapeutics

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NCT07118306Recruiting

COPD Exacerbation Follow Up

The goal of this study is to evaluate the impact of implementing an AI-enabled clinical workflow tool (Viz COPD) on respiratory specialist follow up and clinical outcomes after an acute exacerbation....

Philadelphia, PA485 participantsViz.ai, Inc.

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NCT05997875Recruiting

Transforming Hemodialysis-Related Vascular Access Education

The focus of this study is on vascular access for hemodialysis. This is a randomized clinical trial testing 3 educational approaches to help patients with advanced chronic kidney disease prepare for p...

Philadelphia, PANA360 participantsUniversity of Pennsylvania

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NCT04997642Recruiting

Parkinson's Disease and Movement Disorders Clinical Database

The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and ...

Philadelphia, PA250 participantsUniversity of Pennsylvania

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NCT07227376Recruiting

Data Collection Using Eko Digital Devices in a Clinical Setting

The purpose of this research is to prospectively train and validate an artificial intelligence machine learning (ML) algorithm to detect the presence of adventitious lung sounds in adults. Clinicians ...

Philadelphia, PA250 participantsEko Devices, Inc.

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NCT07205718Recruiting

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

TAK-188 is a new medicine that targets a protein called CCR8, which is found on the surface of certain cells (Tregs) inside tumors. These cells can weaken the body's ability to fight cancer. TAK-188 m...

Philadelphia, PAPHASE1223 participantsTakeda

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NCT01401998Recruiting

ARPKD Database Study

Hepato-renal fibrocystic diseases (HRFD) is a term developed that encompasses rare diseases such as Autosomal Recessive Polycystic Kidney Disease (ARPKD), and other diseases with common features (Joub...

Philadelphia, PA200 participantsChildren's Hospital of Philadelphia

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NCT07094087Recruiting

Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)

This is a phase 3, multicenter, randomized, open-label, parallel-group, controlled study to assess the efficacy and safety of BE1116 compared with fresh frozen plasma (FFP) in adult participants under...

Philadelphia, PAPHASE3200 participantsCSL Behring

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NCT04074720Recruiting

Prospective Breast Cancer Biospecimen Collection

Tissue will be procured during a standard of care procedure the patient will already be scheduled to undergo. A one time blood draw will be performed at this time and an optional rectal swab for biome...

Philadelphia, PA200 participantsThomas Jefferson University

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NCT05422911Recruiting

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

The investigators have used national VHA data to demonstrate real-world efficacy of abiraterone and enzalutamide in Veterans with mCRPC. In the real-world that is the VHA, the investigators have succe...

Philadelphia, PAPHASE2192 participantsSun Pharmaceutical Industries Limited

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NCT06782581Recruiting

CARE Study: Cancer, Asian Americans, and Relationship Enrichment

The overarching goal of the current study is to reduce the burden Asian American patients may feel are on their caregivers by designing and testing the feasibility and efficacy of a positive activity ...

Philadelphia, PANA186 participantsFox Chase Cancer Center

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NCT07159308Recruiting

Motivation for Daily Living Skills

The goal of this clinical trial is to enhance motivation to complete daily living skills among 16 to 25-year-old autistic teens and young adults. Here are the main questions the trial aims to answer: ...

Philadelphia, PANA180 participantsChildren's Hospital of Philadelphia

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NCT06870617Recruiting

Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)

The use of a geriatric assessment to inform oncologic care for older persons with cancer is an evidence-based practice that improves patient-clinician communication, reduces treatment-related toxicity...

Philadelphia, PA150 participantsAbramson Cancer Center at Penn Medicine

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NCT07630974Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

Researchers are looking for new ways to treat children with relapsed or refractory solid tumors: * Relapsed means the cancer came back after treatment * Refractory means the cancer did not respond (g...

Philadelphia, PAPHASE1134 participantsMerck Sharp & Dohme LLC

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NCT06475976Recruiting

Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental ...

Philadelphia, PA130 participantsChildren's Hospital of Philadelphia

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NCT07225751Recruiting

A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

This is a phase IV post-marketing study for MagnetOs Putty and MagnetOs Easypack Putty. MagnetOs is a synthetic bone graft extender product that is routinely used by surgeon as treatment for hindfoot ...

Philadelphia, PANA126 participantsKuros Biosurgery AG

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NCT07305818Recruiting

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into...

Philadelphia, PAPHASE1100 participantsMerida Biosciences

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NCT06936566Recruiting

MAGIC Ruxolitinib for aGVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell transplant. Acute GVHD occurs when donor cel...

Philadelphia, PAPHASE298 participantsJohn Levine

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NCT04959474Recruiting

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

This phase II trial studies the effect of calorie reduction while undergoing stereotactic ablative radiation therapy in treating patients with breast cancer. Stereotactic ablative radiation therapy (s...

Philadelphia, PANA80 participantsThomas Jefferson University

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NCT06994676Recruiting

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

Study CBX-250-001 is a Phase 1, open-label, dose-escalation study of CBX-250 in participants with relapsed/refractory AML, HR-MDS, CMML, and CML. Participants aged ≥ 12 years are planned to be enrolle...

Philadelphia, PAPHASE172 participantsCrossbow Therapeutics, Inc.

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NCT06496243Recruiting

Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels

The goal of this open label 16 week trial is to evaluate Lp(a) levels for patients with elevated Lp(a) being treated with obicetrapib and obiceptrapib/evolocumab Patients will: Have baseline Lp(a) t...

Philadelphia, PAPHASE269 participantsNewAmsterdam Pharma

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NCT07201025Recruiting

Imaging Assessments of ARPKD Kidney Disease Progression

Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a potentially lethal genetic disorder for which there are currently no disease specific treatments. Clinical trials have been limited by the ab...

Philadelphia, PA60 participantsThe Cleveland Clinic

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NCT07316478Recruiting

Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

The purpose of this research is to determine whether a new stress management and mindfulness program can improve quality of life in individuals with sickle cell disease. The program is based on a numb...

Philadelphia, PANA50 participantsUniversity of Pennsylvania

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NCT07123155Recruiting

Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and exploratory clinical efficacy of S-606001 in adult participants with LOPD as an add-on to ERT....

Philadelphia, PAPHASE245 participantsShionogi

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NCT03863457Recruiting

[18F] F-GLN by PET/CT in Breast Cancer

Patients with known or suspected primary or metastatic breast cancer with one lesion that is 1.0 cm in diameter or greater may be eligible for this study. Patients may participate in this study if the...

Philadelphia, PAPHASE140 participantsAbramson Cancer Center at Penn Medicine

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NCT05734404Recruiting

Longitudinal Study for Central Nervous System Vasculitis

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech imp...

Philadelphia, PA40 participantsUniversity of Pennsylvania

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NCT07493512Recruiting

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

The primary objective of this trial is to determine the safety profile of xaluritamig at the proposed regimen in adult participants with metastatic castration-resistant prostate cancer (mCRPC)....

Philadelphia, PAPHASE140 participantsAmgen

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NCT06934382Recruiting

Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma

This will be a Phase 1, open-label study to evaluate the safety and efficacy of BEAM-201 in patients with R/R T-ALL or T-LLy. BEAM-201 is an allogeneic anti-CD7 CART therapy....

Philadelphia, PAPHASE133 participantsStephan Grupp MD PhD

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NCT05659901Recruiting

Rocket Study: A Study to Characterize Biomarkers and Disease Progression in Participants With Pelizaeus-Merzbacher Disease

The purpose of the study is to prospectively assess longitudinal changes in proteolipid protein 1 (PLP1) protein, disease-related biomarkers in cerebral spinal fluid (CSF) and blood, neuroimaging para...

Philadelphia, PA32 participantsIonis Pharmaceuticals, Inc.

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NCT07252050Recruiting

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

This trial will determine whether adding ruxolitinib to a reduced intensity conditioning (RIC) regimen reduces the rate of graft failure following haploidentical (haplo) hematopoietic cell transplant ...

Philadelphia, PAPHASE124 participantsArkansas Children's Hospital Research Institute

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NCT05659797Recruiting

FES BPET-DBT in Newly Diagnosed Breast Cancer

Patients with newly diagnosed primary estrogen-receptor (ER) positive breast cancer, with at least one breast lesion that is 1.0 cm in diameter or greater, may be eligible for this study. Patients may...

Philadelphia, PAEARLY_PHASE120 participantsAbramson Cancer Center at Penn Medicine

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NCT05070013Recruiting

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US. The prevalence of sleep dysfunc...

Philadelphia, PANA20 participantsUniversity of Nebraska

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NCT05106387Recruiting

An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant

The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study...

Philadelphia, PA20 participantsRegeneron Pharmaceuticals

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NCT06613841Recruiting

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

* To perform metabolic phenotyping of treatment naïve and recurrent GBM by multitracer \[18F\]Fluciclovine and 18F-FDG PET. * To compare uptake measures of 18F-Fluciclovine and 18F-FDG and MRI quantif...

Philadelphia, PAEARLY_PHASE115 participantsAbramson Cancer Center at Penn Medicine

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NCT07085039Recruiting

Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease

The research study is being done to look at the effects of ruxolitinib in adults with idiopathic Multicentric Castleman Disease (iMCD) that has not gotten better from taking siltuximab or tocilizumab,...

Philadelphia, PAPHASE214 participantsUniversity of Pennsylvania

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NCT07209241Recruiting

Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

This is an open-label, phase 1b study to evaluate different approaches for CART-EGFR-IL13Ra2 dosing and further characterize the safety, feasibility, preliminary efficacy, and pharmacokinetics of CART...

Philadelphia, PAPHASE112 participantsUniversity of Pennsylvania

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NCT07282847Recruiting

A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late Onset Pompe Disease (PROGRESS-GT LOPD)

This is a single-arm, open-label, dose-escalation study to evaluate the safety, tolerability and efficacy of a single intravenous infusion of AB-1009 in adult participants with late-onset Pompe diseas...

Philadelphia, PAPHASE112 participantsAskBio Inc

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NCT06364774Recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

The main goal of this study is to find out if the blood disorder called transfusion-dependent beta thalassemia can be safely treated by modifying blood stem cells. This is done by collecting blood ste...

Philadelphia, PAPHASE112 participantsChildren's Hospital of Philadelphia

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NCT06192576Recruiting

A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

US, multicenter, cohort, open label observational study with primary data collection. Ancillary protocol-specified procedures to address the study objectives (eg, assessment of ADA) may be considered ...

Philadelphia, PA10 participantsSanofi

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About Ankylosing Spondylitis Clinical Trials in Philadelphia

Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, causing pain, stiffness, and potentially spinal fusion. It typically begins in early adulthood. Treatment includes NSAIDs, biologics (TNF and IL-17 inhibitors), and physical therapy.

There are currently 51 ankylosing spondylitis clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 40,134 participants. Research is being sponsored by Boston Children's Hospital, Abramson Cancer Center at Penn Medicine, Sir Mortimer B. Davis - Jewish General Hospital and 34 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Ankylosing Spondylitis Clinical Trials in Philadelphia — FAQ

Are there ankylosing spondylitis clinical trials in Philadelphia?

Yes, there are 51 ankylosing spondylitis clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What ankylosing spondylitis treatments are being tested?

The 51 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for ankylosing spondylitis.

Data updated July 16, 2026 from ClinicalTrials.gov