8 Depression Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Depression Studies in Philadelphia

NCT05800925Recruiting

Triage Survey for Psychiatry Research Eligibility

TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials....

Philadelphia, PA20,000 participantsAdams Clinical

View Study Details

NCT02463266Recruiting

Evaluation of the PACE/PACENET BHL Clinical Program

The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enr...

Philadelphia, PA4,000 participantsUniversity of Pennsylvania

View Study Details

NCT05748730Recruiting

Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention

This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are f...

Philadelphia, PANA900 participantsUniversity of Pittsburgh

View Study Details

NCT06496646Recruiting

Antidepressant Adherence for Depressed Adults in Primary Care

The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes....

Philadelphia, PANA525 participantsUniversity of Pennsylvania

View Study Details

NCT06700902Recruiting

Taking Action for College Students

The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses. Participants will be ...

Philadelphia, PANA300 participantsTemple University

View Study Details

NCT07226232Recruiting

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S. military Veterans with and without (±) concurrent...

Philadelphia, PAPHASE3240 participantsVA Office of Research and Development

View Study Details

NCT07159061Recruiting

Neurofeedback to Treat Depression - 2

This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD. This real-time fMRI neurofeedback t...

Philadelphia, PANA80 participantsUniversity of Pennsylvania

View Study Details

NCT06788249Recruiting

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

In the treatment of Major Depressive Disorder (MDD), ketamine can produce rapid but short-lasting improvements in mood. In order to develop a new generation of treatments with rapid and sustained effi...

Philadelphia, PAEARLY_PHASE110 participantsUniversity of Pennsylvania

View Study Details

About Depression Clinical Trials in Philadelphia

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 8 depression clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 26,055 participants. Research is being sponsored by Adams Clinical, University of Pennsylvania, University of Pittsburgh and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Philadelphia — FAQ

Are there depression clinical trials in Philadelphia?

Yes, there are 8 depression clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What depression treatments are being tested?

The 8 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated August 28, 2026 from ClinicalTrials.gov