NCT06496646 · University of Pennsylvania
Antidepressant Adherence for Depressed Adults in Primary Care
What this study is about
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
View original scientific description
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
Interventions
BEHAVIORAL
Arm 1 intervention
This description is blinded.
BEHAVIORAL
Arm 2 Intervention
This description is blinded
Primary outcome measures
Depression symptom response 12 weeks
Time frame: 12 weeks from baseline
A reduction of 50% in depression score from baseline as assessed by PHQ-9
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Penn Medicine primary care outpatients
- Clinical diagnosis of major depressive disorder
- A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9)
- Age 21 to 64 years at the time of study entry
- Prescribed an antidepressant by their primary care clinician
- Express interest in taking antidepressant medication
- Own a cell phone
- Capable of using the electronic pill bottle
- English-speaking
Exclusion criteria
- Treated with antidepressants in the past 90 days
- Pregnant or breastfeeding
- An active substance use disorder other than nicotine
- A lifetime history of treatment for bipolar disorder or schizophrenia
- Hospital admission or emergency department visit for suicidal symptoms in the past year
- Lack capacity to provide informed consent
- Using antidepressant more than 10 days at baseline assessment
Where
- Philadelphia, Pennsylvania
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Nov 26, 2025 · Source of record for eligibility and locations