7 Epilepsy Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Epilepsy Studies in Philadelphia

NCT06265103Recruiting

Epilepsy Learning Healthcare System (ELHS)

The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for e...

Philadelphia, PA100,000 participantsEpilepsy Foundation of America

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NCT03419260Recruiting

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electro...

Philadelphia, PA2,500 participantsChildren's Hospital of Philadelphia

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NCT04649008Recruiting

Localizing Epileptic Networks Using MRI and iEEG

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy sur...

Philadelphia, PAEARLY_PHASE1290 participantsUniversity of Pennsylvania

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NCT07010471Recruiting

A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine

A Phase 3, Randomized, Multi-Center, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Relutrigine in Participants with Developmen...

Philadelphia, PAPHASE3160 participantsPraxis Precision Medicines

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NCT07019922Recruiting

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

A Multi-Center, Single-Arm Clinical Trial to Investigate the Efficacy and Safety of Elsunersen in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy...

Philadelphia, PAPHASE340 participantsPraxis Precision Medicines

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NCT07219407Recruiting

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

This is a clinical research study for an investigational drug called RAP-219 in patients with Refractory Focal Epilepsy. This study is being conducted to determine RAP-219 Long- term safety and open-l...

Philadelphia, PAPHASE230 participantsRapport Therapeutics Inc.

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NCT07227857Recruiting

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Study CL1-230815-001 (KANDLE) is a Phase Ib/II, First In Human, multicentre, open-label, multiple ascending dose study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD...

Philadelphia, PAPHASE120 participantsInstitut de Recherches Internationales Servier

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About Epilepsy Clinical Trials in Philadelphia

Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures caused by abnormal electrical activity in the brain. It affects about 50 million people worldwide. Treatment includes antiseizure medications, surgery, and neurostimulation devices.

There are currently 7 epilepsy clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 103,040 participants. Research is being sponsored by Epilepsy Foundation of America, Children's Hospital of Philadelphia, University of Pennsylvania and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Epilepsy Clinical Trials in Philadelphia — FAQ

Are there epilepsy clinical trials in Philadelphia?

Yes, there are 7 epilepsy clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What epilepsy treatments are being tested?

The 7 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for epilepsy.

Data updated July 17, 2026 from ClinicalTrials.gov