47 Osteogenesis Imperfecta Clinical Trials in Philadelphia, PA (2026)

Q: Are there osteogenesis imperfecta clinical trials in Philadelphia?

Yes, there are 47 osteogenesis imperfecta clinical trials currently recruiting in Philadelphia, PA.

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Q: Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Osteogenesis Imperfecta Studies in Philadelphia

NCT06350409Recruiting

Adolescent Outcomes of Post-operative Opioid EXposure

The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical ...

Philadelphia, PA20,000 participantsSharon Levy

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NCT06844045Recruiting

Point of Care STI Testing

The proposed research hypothesizes that point-of-care testing (POCT) for sexually transmitted infections (STIs) gonorrhea and chlamydia will be a feasible, acceptable, and appropriate implementation s...

Philadelphia, PA6,460 participantsIcahn School of Medicine at Mount Sinai

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NCT04098445Recruiting

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Early pulmonary injury includes diffuse alv...

Philadelphia, PA2,000 participantsChildren's Hospital Medical Center, Cincinnati

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NCT05897788Recruiting

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

There is growing recognition of the need for approaches to initiate treatment wherever patients touch the health care system, including the Emergency Department (ED). Most research has focused on init...

Philadelphia, PA1,808 participantsUniversity of Pennsylvania

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NCT07262190Recruiting

NavSTAR Implementation Effectiveness Trial Across a Health System

Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment. Delivering PN interventions on a wide scale requires many resources ...

Philadelphia, PA720 participantsFriends Research Institute, Inc.

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NCT05880199Recruiting

BSGM to Evaluate Patients With GI Symptoms

The goal of this observational study is to learn about gastric myoelectric activity in children with GI symptoms. The main question it aims to answer is which patterns or signals are associated with G...

Philadelphia, PA685 participantsChildren's Hospital of Philadelphia

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NCT04119713Recruiting

Autoimmunity After Checkpoint Blockade

The purpose of this study is to better understand how the treatment of cancer with immune checkpoint inhibitors (ICI) leads to the development of autoimmunity. Specifically, we wish to understand the ...

Philadelphia, PA600 participantsAbramson Cancer Center at Penn Medicine

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NCT04978168Recruiting

Opioid Treatment and Peer Recovery Support

Determine whether a facilitated local change team intervention improves a probation organization's client-level medication for opioid use disorder (MOUD) outcomes and implementation outcomes relative ...

Philadelphia, PA450 participantsBrown University

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NCT06466005Recruiting

UnityPhilly Response App for Overdose Reversal

The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app. The main ...

Philadelphia, PA450 participantsDrexel University

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NCT06073665Recruiting

Dosing of LT4 in Older Individuals

Our overall goal is to determine the clinical consequences of allowing greater flexibility in LT4 dosing in older individuals who take LT4....

Philadelphia, PA228 participantsUniversity of Pennsylvania

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NCT06136247Recruiting

Integrating Brain, Neurocognitive, and Computational Tools in OUD

The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common...

Philadelphia, PA192 participantsUniversity of Pennsylvania

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NCT05995535Recruiting

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal

A placebo-controlled trial in which male and female outpatients with an opioid use disorder who express interest in extended-release injectable naltrexone (XR-NTX) are randomized 1:1 to lofexidine/pre...

Philadelphia, PA150 participantsUniversity of Pennsylvania

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NCT02469662Recruiting

Clinical Outcomes Study of the Nexel Total Elbow

The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement....

Philadelphia, PA134 participantsZimmer Biomet

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NCT04276870Recruiting

Orphan Indications for CD19 Redirected Autologous T Cells

This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very h...

Philadelphia, PA133 participantsStephan Grupp MD PhD

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NCT07003100Recruiting

A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

This study is being done to assess mogamulizumab-associated rash in patients diagnosed with mycosis fungoides or sezary syndrome and treated with standard of care mogamulizumab. One of the most common...

Philadelphia, PA100 participantsCity of Hope Medical Center

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NCT06205121Recruiting

Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis

This is a Phase 2, randomized, double-blind, placebo-controlled, adaptive, multicenter study to evaluate the efficacy, safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of OATD-01...

Philadelphia, PA96 participantsMolecure S.A.

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NCT05957367Recruiting

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

This is a Phase 1/2, multicenter, open-label (unless otherwise specified in a combination-specific module) study of inlexisertib in combination with anticancer therapies. Modules within the master pro...

Philadelphia, PA94 participantsDeciphera Pharmaceuticals, LLC

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NCT06705075Recruiting

Evaluation of Uterine Fibroids by CEUS and SHAPE Pre and Post UAE

This study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra...

Philadelphia, PA80 participantsThomas Jefferson University

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NCT03011814Recruiting

Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

This randomized phase I/II trial studies the best dose and side effects of durvalumab and to see how well it works with or without lenalidomide in treating patients with cutaneous or peripheral T cell...

Philadelphia, PA78 participantsCity of Hope Medical Center

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NCT06562881Recruiting

Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism

The goal of this study is to address surgical health equity in historically marginalized participants with primary hyperparathyroidism (PHPT). The main questions that this study aims to answer are, ho...

Philadelphia, PA76 participantsUniversity of Pennsylvania

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NCT06918223Recruiting

Assessing Patient Satisfaction and Confidence After Use of Educational Video to Augment Surgical Consent for Thyroid Surgery

This study looks at how a short educational video can help people better understand thyroid surgery. Patients who have thyroid nodules and need surgery will be part of the study. Some patients will ge...

Philadelphia, PA60 participantsThomas Jefferson University

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NCT06379984Recruiting

Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants...

Philadelphia, PA60 participantsUniversity of Pennsylvania

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NCT05442216Recruiting

Tagraxofusp and Azaxitadine With or Without Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

A treatment cycle is 28 days for Cycle 1 and Cycle 2. Tagraxofusp will be administered at 12 mcg/kg IV over 15 minutes (-5 or +15 minutes) daily for 5 consecutive days (or 5 doses over a period not to...

Philadelphia, PA53 participantsJoshua Zeidner

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NCT06533098Recruiting

A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

The purpose of this study is to assess the efficacy and safety of nipocalimab in reducing the risk of severe fetal and neonatal alloimmune thrombocytopenia (FNAIT)....

Philadelphia, PA50 participantsJanssen Research & Development, LLC

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NCT06576323Recruiting

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies ...

Philadelphia, PA50 participantsUniversity of Pennsylvania

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NCT07012044Recruiting

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

This phase I trial tests the safety, side effects, and best dose of ASTX727 and filgrastim for the treatment of children with high risk acute myeloid leukemia that has come back after a period of impr...

Philadelphia, PA47 participantsNational Cancer Institute (NCI)

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NCT06510894Recruiting

Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression

This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT. The investigators will test whethe...

Philadelphia, PA40 participantsUniversity of Pennsylvania

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NCT06786325Recruiting

Wellcome Leap Psilocybin for OUD

Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocog...

Philadelphia, PA36 participantsAnna Rose Childress, Ph.D.

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NCT04925479Recruiting

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

The aim of this study is to support development of asciminib in the pediatric population (1 to \<18 years) previously treated with one or more TKIs. Full extrapolation of the efficacy of asciminib fro...

Philadelphia, PA34 participantsNovartis Pharmaceuticals

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NCT05024929Recruiting

Targeted Therapy to Increase RAI Uptake in Metastatic DTC

Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that bloc...

Philadelphia, PA32 participantsChildren's Hospital of Philadelphia

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NCT05668962Recruiting

Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-ref...

Philadelphia, PA30 participantsMassachusetts General Hospital

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NCT06222580Recruiting

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

This phase I trial tests the safety, side effects, and best dose of SNDX-5613 and gilteritinib for treating patients with acute myeloid leukemia that has come back after a period of improvement (relap...

Philadelphia, PA30 participantsUma Borate

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NCT07464951Recruiting

CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia

This study is designed to evaluate the safety and effectiveness of CART123 cells either alone or when combined with ruxolitinib in pediatric and young adult subjects with relapsed or refractory AML. S...

Philadelphia, PA30 participantsStephan Grupp MD PhD

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NCT06643988Recruiting

Autobiographical Memory in Opioid Use Disorder

The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD. F...

Philadelphia, PA30 participantsUniversity of Pennsylvania

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NCT06978725Recruiting

A Phase 2 Study of the Safety and Efficacy of Brepocitinib in Adults With Cutaneous Sarcoidosis (BEACON)

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with cutaneous sarcoidosis....

Philadelphia, PA28 participantsPriovant Therapeutics, Inc.

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NCT07211386Recruiting

The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)

This study will target patients with gastrointestinal (GI) malignancy who present to any of 4 Penn Medicine emergency departments (EDs) with intractable abdominal pain. We will offer eligible patients...

Philadelphia, PA25 participantsAbramson Cancer Center at Penn Medicine

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NCT06877858Recruiting

MethaLoad Dose-Finding Study

The goal of this study is to develop a loading dose approach to starting methadone to treat opioid use disorder with fentanyl use ("fentanyl OUD", herein). This study is a participant- and assessor- b...

Philadelphia, PA24 participantsUniversity of Pennsylvania

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NCT06643884Recruiting

Suprachoroidal Administration in Subjects With Choroidal Metastasis From Breast or Lung Primary Tumors

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with choroidal metastasis from breast or lung primary tumors....

Philadelphia, PA24 participantsAura Biosciences

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NCT06177067Recruiting

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

This is a research study to find out if adding a new study drug called revumenib to commonly used chemotherapy drugs is safe and if they have beneficial effects in treating patients with acute myeloid...

Philadelphia, PA24 participantsSt. Jude Children's Research Hospital

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NCT06810310Recruiting

Psilocybin on Brain Mechanisms of Motivation in OUD

The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 fr...

Philadelphia, PA24 participantsUniversity of Pennsylvania

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NCT05627232Recruiting

Tazemetostat and Palbociclib With CPX-351for R/R AML

This is a two-part phase Ib dose escalation study to evaluate the safety and preliminary efficacy of the combination of tazemetostat and CPX-351 (Part 1) and of pre-treatment with palbociclib followed...

Philadelphia, PA24 participantsThomas Jefferson University

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NCT04990102Recruiting

Phase IB/II of CPX-351 for Relapse Prevention in AML

This is a phase IB/II study with a 3+3 dose de-escalation study design. Patients will continue maintenance treatment with CPX-351 for 6 cycles on D1 and D3, as long as patient remains in CR. The dose ...

Philadelphia, PA24 participantsGeorgetown University

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NCT06969261Recruiting

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by...

Philadelphia, PA20 participantsUniversity of Pennsylvania

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NCT05945849Recruiting

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

The purpose of this study is to provide a new type of treatment for AML. This treatment combines a new type of stem cell transplant along with treatment using chimeric antigen receptor (CAR) T cells t...

Philadelphia, PA16 participantsUniversity of Pennsylvania

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NCT06730126Recruiting

Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients

Background: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of the immune system caused by a mutation in the FAS gene. In ALPS, the body stores too many germ-fighting cells called l...

Philadelphia, PA15 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05783323Recruiting

Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioacti...

Philadelphia, PA13 participantsChildren's Hospital of Philadelphia

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NCT06458036Recruiting

Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)

Philadelphia, PA13 participantsChildren's Hospital of Philadelphia

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About Osteogenesis Imperfecta Clinical Trials in Philadelphia

Osteogenesis imperfecta is a group of genetic disorders mainly affecting the bones, causing them to break easily, often from little or no apparent cause. It is caused by defects in collagen production. Treatment includes bisphosphonates, physical therapy, and surgical rodding.

There are currently 47 osteogenesis imperfecta clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 35,390 participants. Research is being sponsored by Sharon Levy, Icahn School of Medicine at Mount Sinai, Children's Hospital Medical Center, Cincinnati and 24 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Osteogenesis Imperfecta Clinical Trials in Philadelphia — FAQ

Are there osteogenesis imperfecta clinical trials in Philadelphia?

Yes, there are 47 osteogenesis imperfecta clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What osteogenesis imperfecta treatments are being tested?

The 47 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for osteogenesis imperfecta.

Data updated July 13, 2026 from ClinicalTrials.gov