12 Substance Use Disorder Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Substance Use Disorder Studies in Philadelphia

NCT06350409Recruiting

Adolescent Outcomes of Post-operative Opioid EXposure

The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical ...

Philadelphia, PA20,000 participantsSharon Levy

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NCT07262190Recruiting

NavSTAR Implementation Effectiveness Trial Across a Health System

Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment. Delivering PN interventions on a wide scale requires many resources ...

Philadelphia, PANA720 participantsFriends Research Institute, Inc.

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NCT06136247Recruiting

Integrating Brain, Neurocognitive, and Computational Tools in OUD

The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common...

Philadelphia, PA192 participantsUniversity of Pennsylvania

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NCT05028062Recruiting

Naltrexone in AUD Reward Drinkers

This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heav...

Philadelphia, PAPHASE460 participantsUniversity of Pennsylvania

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NCT06379984Recruiting

Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants...

Philadelphia, PAPHASE260 participantsUniversity of Pennsylvania

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NCT06576323Recruiting

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies ...

Philadelphia, PANA50 participantsUniversity of Pennsylvania

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NCT06786325Recruiting

Wellcome Leap Psilocybin for OUD

Investigators will recruit 36 individuals on MAT for OUD for a double-blind, placebo-controlled design to determine whether PEX010 (25-mg/d) shows preliminary efficacy on neural correlates of neurocog...

Philadelphia, PAPHASE236 participantsAnna Rose Childress, Ph.D.

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NCT06643988Recruiting

Autobiographical Memory in Opioid Use Disorder

The research study is being conducted to better understand memory function in people with opioid use disorder (OUD) and whether memory training can improve the symptoms and lives of people with OUD. F...

Philadelphia, PANA30 participantsUniversity of Pennsylvania

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NCT06559995Recruiting

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with mo...

Philadelphia, PAPHASE230 participantsUniversity of Pennsylvania

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NCT06810310Recruiting

Psilocybin on Brain Mechanisms of Motivation in OUD

The goal of this study is to test addiction-related brain circuitry (motivation/reward and inhibition) as well as neurocognitive circuitry prior to and following low or high dose psilocybin (PEX010 fr...

Philadelphia, PAPHASE224 participantsUniversity of Pennsylvania

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NCT06877858Recruiting

MethaLoad Dose-Finding Study

The goal of this study is to develop a loading dose approach to starting methadone to treat opioid use disorder with fentanyl use ("fentanyl OUD", herein). This study is a participant- and assessor- b...

Philadelphia, PAPHASE124 participantsUniversity of Pennsylvania

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NCT06969261Recruiting

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by...

Philadelphia, PANA20 participantsUniversity of Pennsylvania

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About Substance Use Disorder Clinical Trials in Philadelphia

Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.

There are currently 12 substance use disorder clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 21,246 participants. Research is being sponsored by Sharon Levy, Friends Research Institute, Inc., University of Pennsylvania and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Substance Use Disorder Clinical Trials in Philadelphia — FAQ

Are there substance use disorder clinical trials in Philadelphia?

Yes, there are 12 substance use disorder clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What substance use disorder treatments are being tested?

The 12 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for substance use disorder.

Data updated August 28, 2026 from ClinicalTrials.gov