14 Systemic Lupus Erythematosus Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Systemic Lupus Erythematosus Studies in Philadelphia

NCT05703347Recruiting

Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children

The overall objective of this application is to develop a mobile health platform for the pediatric care setting to promote longer sleep duration for childhood obesity prevention....

Philadelphia, PANA5,000 participantsChildren's Hospital of Philadelphia

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NCT06189755Recruiting

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop an...

Philadelphia, PA500 participantsUniversity of Pennsylvania

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NCT05382754Recruiting

Home Apnea Testing in CHildren Trial

This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in ch...

Philadelphia, PANA317 participantsChildren's Hospital of Philadelphia

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NCT06043440Recruiting

Down Syndrome Obstructive Sleep Apnea

The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) w...

Philadelphia, PAPHASE2230 participantsBrigham and Women's Hospital

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NCT07280468Recruiting

Endotype DIrected Treatment for OSA in Down Syndrome

Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing...

Philadelphia, PAPHASE4200 participantsUniversity of Arizona

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NCT06963463Recruiting

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep diff...

Philadelphia, PANA90 participantsUniversity of Pittsburgh

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NCT04457154Recruiting

Pediatric Post-Approval Registry

This registry is a prospective, multi-center, single-arm study of pediatric subjects (ages 18-21 years) who are undergoing implant of the Inspire Upper Airway Stimulation (UAS) System for the treatmen...

Philadelphia, PA60 participantsInspire Medical Systems, Inc.

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NCT04191512Recruiting

Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.

To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation. With this study ...

Philadelphia, PA50 participantsThomas Jefferson University

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NCT06789770Recruiting

Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep

This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sle...

Philadelphia, PA50 participantsUniversity of Pennsylvania

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NCT05039619Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

This phase II, randomized, double-blind, placebo-controlled study is designed to evaluate the safety, efficacy and pharmacokinetics (PK) of obinutuzumab in adolescent participants (AP) aged 12 to less...

Philadelphia, PAPHASE240 participantsHoffmann-La Roche

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NCT06839976Recruiting

CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

This is a single-center, single-arm, open-label phase 1/2 study of CART19 in children and young adults with refractory Systemic lupus erythematosus (SLE), including both patients diagnosed with lupus ...

Philadelphia, PAPHASE124 participantsChildren's Hospital of Philadelphia

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NCT07328581Recruiting

A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary cli...

Philadelphia, PAPHASE220 participantsiCell Gene Therapeutics

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NCT05029336Recruiting

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

A subset of autoimmune diseases (ADs) in children and young adults are life-threatening and unresponsive to conventional treatments. In these patients, the delivery of high dose immunosuppressive ther...

Philadelphia, PAPHASE220 participantsStephan Grupp MD PhD

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NCT06642246Recruiting

Sleep Promotion and Pediatric Hypertension

Determine the effectiveness and feasibility of a mobile health sleep extension approach in the pediatric nephrology setting, to increase sleep duration and reduce systolic and diastolic blood pressure...

Philadelphia, PANA10 participantsChildren's Hospital of Philadelphia

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About Systemic Lupus Erythematosus Clinical Trials in Philadelphia

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect the joints, skin, kidneys, blood cells, brain, heart, and lungs. It is characterized by periods of flares and remission. Treatment includes antimalarials, immunosuppressants, corticosteroids, and biologics like belimumab.

There are currently 14 systemic lupus erythematosus clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 6,611 participants. Research is being sponsored by Children's Hospital of Philadelphia, University of Pennsylvania, Brigham and Women's Hospital and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Systemic Lupus Erythematosus Clinical Trials in Philadelphia — FAQ

Are there systemic lupus erythematosus clinical trials in Philadelphia?

Yes, there are 14 systemic lupus erythematosus clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What systemic lupus erythematosus treatments are being tested?

The 14 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for systemic lupus erythematosus.

Data updated October 15, 2026 from ClinicalTrials.gov