7 Major Depressive Disorder Clinical Trials in Phoenix, AZ (2026)

Q: How do I join a clinical trial in Phoenix?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Phoenix research site will contact you.

Recruiting Major Depressive Disorder Studies in Phoenix

NCT06830044Recruiting

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

The purpose of this study is to determine the efficacy and safety of milsaperidone compared to placebo as adjunctive therapy in patients with Major Depressive Disorder...

Phoenix, AZPHASE3500 participantsVanda Pharmaceuticals

View Study Details

NCT05922878Recruiting

Study of ALTO-300 in MDD

The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics....

Phoenix, AZPHASE2321 participantsAlto Neuroscience

View Study Details

NCT06633016Recruiting

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who ha...

Phoenix, AZPHASE2230 participantsAutobahn Therapeutics, Inc.

View Study Details

NCT07276997Recruiting

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and phy...

Phoenix, AZPHASE2195 participantsAbbVie

View Study Details

NCT07553637Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD....

Phoenix, AZPHASE2178 participantsAlto Neuroscience

View Study Details

NCT07115329Recruiting

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does ze...

Phoenix, AZPHASE2164 participantsSyndeio Biosciences, Inc

View Study Details

NCT07610473Recruiting

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

In this study, researchers will learn more about a study drug called DT-101 in participants with Major Depressive Disorder (MDD), a form of depression. The goal of this clinical trial is to learn if D...

Phoenix, AZPHASE2118 participantsDraig Therapeutics Ltd

View Study Details

About Major Depressive Disorder Clinical Trials in Phoenix

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 7 major depressive disorder clinical trials recruiting participants in Phoenix, AZ. These studies are seeking a combined 1,706 participants. Research is being sponsored by Vanda Pharmaceuticals, Alto Neuroscience, Autobahn Therapeutics, Inc. and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Phoenix — FAQ

Are there major depressive disorder clinical trials in Phoenix?

Yes, there are 7 major depressive disorder clinical trials currently recruiting in Phoenix, AZ. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Phoenix?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Phoenix research site will contact you about next steps.

Are clinical trials in Phoenix free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Phoenix studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 7 active trials in Phoenix are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov