7 Head and Neck Cancer Clinical Trials in Rochester, MN (2026)

Q: How do I join a clinical trial in Rochester?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you.

Recruiting Head and Neck Cancer Studies in Rochester

NCT06356272Recruiting

Oropharynx (OPX) Biomarker Trial

The purpose of this research is to identify a biomarker that is exists when human papillomavirus (HPV) mediated oropharyngeal squamous cell carcinoma is present and does not exist when HPV mediated or...

Rochester, MN560 participantsMayo Clinic

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NCT05541016Recruiting

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

This phase II trial examines the use of blood-based biomarkers is to help inform decision making for treatment and radiation therapy for patients with human papillomavirus (HPV) positive oropharyngeal...

Rochester, MNPHASE2455 participantsMayo Clinic

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NCT04915183Recruiting

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

Background: Cisplatin is used to treat head and neck cancer. People who take this drug are at risk for hearing loss. Atorvastatin is a drug used to treat high cholesterol. It might reduce the risk of...

Rochester, MNPHASE2224 participantsNational Institute on Deafness and Other Communication Disorders (NIDCD)

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NCT04564989Recruiting

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating...

Rochester, MN220 participantsUNC Lineberger Comprehensive Cancer Center

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NCT06115772Recruiting

Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma, PAP-OP Study

This study evaluates how often women with throat (oropharyngeal) cancer or who have a partner with oropharyngeal cancer get anogenital infections with high risk, potentially cancer-causing types of hu...

Rochester, MN154 participantsMayo Clinic

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NCT06769698Recruiting

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

This study is researching an experimental drug called fianlimab (also called REGN3767), combined with a medication called cemiplimab compared against cemiplimab combined with placebo (a placebo looks ...

Rochester, MNPHASE2120 participantsRegeneron Pharmaceuticals

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NCT04805528Recruiting

Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck

The purpose of this study would like to learn if acupuncture-like electrical therapy can be used in patients with head and neck cancer who have had radiation treatment to treat dry mouth....

Rochester, MNNA75 participantsUniversity of Rochester

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About Head and Neck Cancer Clinical Trials in Rochester

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 7 head and neck cancer clinical trials recruiting participants in Rochester, MN. These studies are seeking a combined 1,808 participants. Research is being sponsored by Mayo Clinic, National Institute on Deafness and Other Communication Disorders (NIDCD), UNC Lineberger Comprehensive Cancer Center and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Rochester — FAQ

Are there head and neck cancer clinical trials in Rochester?

Yes, there are 7 head and neck cancer clinical trials currently recruiting in Rochester, MN. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Rochester?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you about next steps.

Are clinical trials in Rochester free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Rochester studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 7 active trials in Rochester are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated August 27, 2026 from ClinicalTrials.gov