28 HIV AIDS Clinical Trials in San Francisco, CA (2026)

Q: How do I join a clinical trial in San Francisco?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you.

Recruiting HIV AIDS Studies in San Francisco

NCT00187512Recruiting

SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era

SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to exa...

San Francisco, CA2,500 participantsUniversity of California, San Francisco

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NCT01336855Recruiting

Collection of Blood for Multiple Collaborative Studies

This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies....

San Francisco, CA2,000 participantsUniversity of California, San Francisco

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NCT07682961Recruiting

Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy

The goal of this clinical study is to compare how effective a long-acting injectable treatment of lenacapavir (LEN), teropavimab (TAB), and zinlirvimab (ZAB) versus (CAB) and rilpivirine (RPV) injecti...

San Francisco, CAPHASE3590 participantsGilead Sciences

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NCT05887557Recruiting

Multidisciplinary Low-Barrier and Mobile HIV Care to Improve Retention and Viral Suppression: Stakeholder-Engaged Design and Evaluation

The purpose of this study is to evaluate the implementation and effectiveness of a flexible, multidisciplinary, integrated drop-in/mobile HIV care approach for people living with HIV (PLH) who are not...

San Francisco, CANA400 participantsUniversity of California, San Francisco

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NCT04855773Recruiting

Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention

The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directe...

San Francisco, CANA300 participantsPublic Health Foundation Enterprises, Inc.

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NCT07438041Recruiting

Linking Youth to Pre-Exposure Prophylaxis (PrEP) Services

The LYPS intervention is a multi-level intervention that combines: a) structural-level delivery of PrEP and PrEP services by a community health professional (CHP) at a designated place in the communit...

San Francisco, CANA272 participantsWestat

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NCT05642858Recruiting

Text Education About Cardiovascular Health and HIV (TEACH-HIV)

The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH)....

San Francisco, CANA260 participantsUniversity of California, San Francisco

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NCT06263426Recruiting

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV....

San Francisco, CANA200 participantsJohns Hopkins University

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NCT07510048Recruiting

Combatting HIV Or Other STIs Early (CHOOSE)

The overarching goal of this project is to optimize the PrEP Choice integrated mHealth package and assess the efficacy and cost of PrEP Choice on PrEP initiation and adherence among young people. It i...

San Francisco, CANA200 participantsWestat

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NCT07645287Recruiting

A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1

The study will have two parts: Part A and Part B. In Part A, the goal of the study is to compare the effectiveness of switching to the study drugs GS-3242 plus Lenacapavir (LEN) versus continuing Bikt...

San Francisco, CAPHASE2175 participantsGilead Sciences

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NCT06856174Recruiting

Menopausal HT for Women Living With HIV (HoT)

Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This corre...

San Francisco, CAPHASE4105 participantsAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

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NCT01161199Recruiting

The Use of Leukapheresis to Support HIV Pathogenesis Studies

Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable ch...

San Francisco, CA100 participantsUniversity of California, San Francisco

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NCT07284082Recruiting

The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. T...

San Francisco, CA90 participantsUniversity of California, San Francisco

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NCT07390955Recruiting

A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1

This study is testing a lab-made antibody called ePGT121v1-LS that targets a specific part of HIV. Researchers will give it by vein (IV) and under the skin (SC), both on its own and together with two ...

San Francisco, CAPHASE183 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07665372Recruiting

Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)

This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without H...

San Francisco, CANA80 participantsJohns Hopkins University

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NCT06631365Recruiting

PrEPsmart 2-1-1 Pilot

This is a pilot study to assess the feasibility, acceptability, and preliminary effectiveness of pre-exposure prophylaxis (PrEP)smart among cisgender sexual minority males (SMM) taking on-demand PrEP ...

San Francisco, CAPHASE260 participantsPublic Health Foundation Enterprises, Inc.

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NCT07757802Recruiting

Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults

This Phase 1 study will evaluate the safety, tolerability, and immune responses of investigational CH505 HIV vaccine regimens in adults in overall good health without HIV. Participants will receive CH...

San Francisco, CAPHASE154 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT01202305Recruiting

The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has fo...

San Francisco, CA50 participantsUniversity of California, San Francisco

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NCT05719441Recruiting

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

A5388 is a phase II, two-arm, randomized, double-blind, placebo-controlled study that will enroll 48 antiretroviral therapy (ART)-naïve adults with acute HIV infection (AHI) in order to determine whet...

San Francisco, CAPHASE248 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06796686Recruiting

Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

This is a partially randomized, open-label phase 1 study to evaluate the safety and immunogenicity of a priming regimen of 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum followed by boosts with Hx...

San Francisco, CAPHASE142 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06665646Recruiting

Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706

The clinical schedule will consist of 3 injections of CD40.HIVRI.Env (VRIPRO) at weeks 0, 4, and 24.40 volunteers without HIV and in overall good health, aged 18 to 60 years, who previously participat...

San Francisco, CAPHASE140 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT04359186Recruiting

SCOPE Analytic Treatment Interruption Protocol

The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART)...

San Francisco, CANA40 participantsUniversity of California, San Francisco

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NCT05985642Recruiting

Observational PIC Destination Cohort

This study is being done to see if people who control HIV without antiretroviral therapy (ART) after receiving an intervention can remain off ART safely. The information collected in this study is als...

San Francisco, CA30 participantsAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

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NCT03684655Recruiting

Imaging Immune Activation in HIV by PET-MR

This is a single center exploratory imaging study involving one intravenous microdose of \[18F\]F-AraG followed by whole-body positron emission tomography-magnetic resonance (PET-MR) imaging in HIV in...

San Francisco, CAPHASE230 participantsCellSight Technologies, Inc.

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NCT03729752Recruiting

PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)

This is a single center exploratory imaging study involving one intravenous microdose of 89Zr-DFO-VRC01 followed by whole-body PET-MR imaging in HIV infected individuals and healthy volunteers. Imagin...

San Francisco, CAPHASE130 participantsUniversity of California, San Francisco

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NCT07216794Recruiting

Small Trial of Alendronate Impact on the Reservoir of HIV

This clinical trial is designed to test the effects of alendronate (ALN) on people living with HIV who are already receiving antiretroviral therapy (ART). Participants are randomly assigned in a 2:1 r...

San Francisco, CAPHASE230 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT04648046Recruiting

CAR-T Cells for HIV Infection

This is a limited-center, open-label dose escalating phase I/IIa study of autologous T cells expressing LVgp120duoCAR molecules in people with HIV infection. It will follow a 3+3 design. Dose escalati...

San Francisco, CAPHASE118 participantsSteven Deeks

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NCT07181486Recruiting

Safety Study of MucoCept-CVN

MucoCept-CVN uses a Lactobacillus strain native to the human vagina that is modified into a live biotherapeutic product (LBP) that continuously expresses a potent anti-HIV drug. If research shows that...

San Francisco, CAPHASE112 participantsCraig Cohen, MD, MPH

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About HIV AIDS Clinical Trials in San Francisco

HIV (human immunodeficiency virus) attacks the immune system and, if untreated, can lead to AIDS (acquired immunodeficiency syndrome). Antiretroviral therapy (ART) can control the virus and prevent transmission. Research continues to pursue a functional cure, long-acting therapies, and preventive vaccines.

There are currently 28 hiv aids clinical trials recruiting participants in San Francisco, CA. These studies are seeking a combined 7,839 participants. Research is being sponsored by University of California, San Francisco, Gilead Sciences, Public Health Foundation Enterprises, Inc. and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

HIV AIDS Clinical Trials in San Francisco — FAQ

Are there hiv aids clinical trials in San Francisco?

Yes, there are 28 hiv aids clinical trials currently recruiting in San Francisco, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Francisco?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Francisco research site will contact you about next steps.

Are clinical trials in San Francisco free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Francisco studies also compensate for your time and travel.

What hiv aids treatments are being tested?

The 28 active trials in San Francisco are testing new therapies including novel drugs, biologics, and treatment approaches for hiv aids.

Data updated October 9, 2026 from ClinicalTrials.gov