11 Colorectal Cancer Clinical Trials in St Louis, MO (2026)

Q: How do I join a clinical trial in St Louis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you.

Recruiting Colorectal Cancer Studies in St Louis

NCT07069556Recruiting

ColoSense Post-Approval Study

The post-approval study (PAS) described here will supplement existing data generated in the CRC-PREVENT clinical trial. The primary outcomes of this supplemental study will include: clinical sensitivi...

St Louis, MO12,500 participantsGeneoscopy, Inc.

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NCT02328677Recruiting

ColoCare Study - Colorectal Cancer Cohort

ColoCare is an international prospective cohort study of stage I-IV colorectal cancer patients (ICD-10 C18-C20)....

St Louis, MO5,000 participantsUniversity of Utah

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NCT05234177Recruiting

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care t...

St Louis, MO300 participantsTempus AI

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NCT07127874Recruiting

A Study of PHN-012 in Patients With Advanced Solid Tumors

This first-in-human study will evaluate safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of PHN-012, a novel antibody-drug conjugate (ADC), in patients ...

St Louis, MOPHASE1165 participantsPheon Therapeutics

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NCT04339374Recruiting

Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

The purpose of this study is to demonstrate the functionality of a novel endorectal photoacoustic ultrasound imaging modality in humans with rectal cancer. The study involves testing a previously deve...

St Louis, MONA90 participantsWashington University School of Medicine

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NCT07058012Recruiting

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

The NSABP FC-13 study is being done to determine if using immunotherapies alone or in combination with other drugs will delay or prevent colorectal cancer from coming back in patients with colorectal ...

St Louis, MOPHASE279 participantsNSABP Foundation Inc

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NCT06910657Recruiting

IDOV-Immune for Advanced Solid Tumors

This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standar...

St Louis, MOPHASE178 participantsViroMissile, Inc.

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NCT07446322Recruiting

FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer

This is an open-label, randomized, multicenter Phase 2 study to assess the efficacy and safety of FOLFIRI + bevacizumab + pelareorep vs. FOLFIRI + bevacizumab in patients with RAS-mutated, MSS mCRC wh...

St Louis, MOPHASE260 participantsOncolytics Biotech

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NCT03516708Recruiting

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is...

St Louis, MOPHASE149 participantsWashington University School of Medicine

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NCT06459869Recruiting

NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

The FORTRESS trial (NG-350A-03) is an open-label, single-arm, and multicentre trial of NG-350A in combination with chemoradiotherapy (CRT) in adult patients with locally advanced rectal cancer (LARC) ...

St Louis, MOPHASE130 participantsAkamis Bio

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NCT05803382Recruiting

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it f...

St Louis, MOPHASE130 participantsNational Cancer Institute (NCI)

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About Colorectal Cancer Clinical Trials in St Louis

Colorectal cancer starts in the colon or rectum and is the third most common cancer diagnosed in both men and women. Early detection through screening significantly improves outcomes. Treatments include surgery, chemotherapy, radiation, and targeted therapies.

There are currently 11 colorectal cancer clinical trials recruiting participants in St Louis, MO. These studies are seeking a combined 18,381 participants. Research is being sponsored by Geneoscopy, Inc., University of Utah, Tempus AI and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Colorectal Cancer Clinical Trials in St Louis — FAQ

Are there colorectal cancer clinical trials in St Louis?

Yes, there are 11 colorectal cancer clinical trials currently recruiting in St Louis, MO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in St Louis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you about next steps.

Are clinical trials in St Louis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many St Louis studies also compensate for your time and travel.

What colorectal cancer treatments are being tested?

The 11 active trials in St Louis are testing new therapies including novel drugs, biologics, and treatment approaches for colorectal cancer.

Data updated July 18, 2026 from ClinicalTrials.gov