Recruiting Heart Failure Studies in St Louis
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute dec...
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesi...
The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients
The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed me...
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
This is a Phase 2 dose-finding study in adult participants with symptomatic HFpEF....
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which ...
About Heart Failure Clinical Trials in St Louis
Heart failure is a chronic condition where the heart cannot pump blood efficiently to meet the body's needs. It affects millions of people worldwide and can result from various heart conditions. Treatment includes medications, lifestyle changes, devices, and in severe cases, heart transplant.
There are currently 5 heart failure clinical trials recruiting participants in St Louis, MO. These studies are seeking a combined 1,084 participants. Research is being sponsored by Reprieve Cardiovascular, Inc, Merck Sharp & Dohme LLC, University of Michigan and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.
Heart Failure Clinical Trials in St Louis — FAQ
Are there heart failure clinical trials in St Louis?
Yes, there are 5 heart failure clinical trials currently recruiting in St Louis, MO. Browse the studies on this page to find one that fits.
How do I join a clinical trial in St Louis?
Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you about next steps.
Are clinical trials in St Louis free?
Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many St Louis studies also compensate for your time and travel.
What heart failure treatments are being tested?
The 5 active trials in St Louis are testing new therapies including novel drugs, biologics, and treatment approaches for heart failure.
Data updated March 2, 2026 from ClinicalTrials.gov