18 Lymphoma Clinical Trials in St Louis, MO (2026)

Q: How do I join a clinical trial in St Louis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you.

Recruiting Lymphoma Studies in St Louis

NCT06526793Recruiting

AZD0486 as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of AZD0486 monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lympho...

St Louis, MOPHASE2270 participantsAstraZeneca

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NCT05079282Recruiting

Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

This study will investigate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ONO-4685 in patients with relapsed or refractory T cell Lymphoma...

St Louis, MOPHASE1217 participantsOno Pharmaceutical Co., Ltd.

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NCT07082803Recruiting

TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies i...

St Louis, MOPHASE1180 participantsTreeline Biosciences, Inc.

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NCT06745076Recruiting

Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

This phase II trial tests how well personalized reduction of chemotherapy (nivolumab, doxorubicin, vinblastine and dacarbazine) based on circulating tumor deoxyribonucleic acid (ctDNA) evaluation work...

St Louis, MOPHASE2125 participantsUniversity of Washington

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NCT06238648Recruiting

Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy

This phase II trial compares epcoritamab to standard practice (observation) for the treatment of patients with B-cell lymphomas who are not in complete remission after treatment with CD19-directed chi...

St Louis, MOPHASE2120 participantsAcademic and Community Cancer Research United

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NCT05643742Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

This is an open-label, multicenter, Phase 1/2 study evaluating the safety and efficacy of CTX112™ in subjects with relapsed or refractory B-cell malignancies....

St Louis, MOPHASE1120 participantsCRISPR Therapeutics AG

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NCT06528301Recruiting

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

This study is a Phase 1 dose-escalation and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV111. The study will enroll patients with relapsed/refractory large B-cell lymp...

St Louis, MOPHASE1106 participantsUmoja Biopharma

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NCT06634589Recruiting

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with BGB-16673 in combination with other agents in participants with relapsed...

St Louis, MOPHASE180 participantsBeiGene

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NCT07015242Recruiting

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

The purpose of this study is to evaluate the safety and efficacy of lisocabtagene maraleucel (Breyanzi/liso-cel/BMS-986387) in adults as first-line treatment in transplant-ineligible Primary Central N...

St Louis, MOPHASE265 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT06854003Recruiting

BRAZAN Trial in Frontline MCL

This study aims to evaluate the efficacy and safety of an induction regimen combining Bendamustine, Rituximab, Cytarabine (AraC), and Zanubrutinib (BRAZAN), followed by maintenance therapy with Zanubr...

St Louis, MOPHASE260 participantsChristine Ryan

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NCT06733441Recruiting

A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma

The primary purpose of this study is to evaluate the anti-tumor activity of TLN-254 monotherapy in participants with relapsed or refractory T-cell lymphoma....

St Louis, MOPHASE150 participantsTreeline Biosciences, Inc.

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NCT07121946Recruiting

This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma

This study is a first-in-human (FIH), Phase 1, multicenter, open-label study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and evaluate the preliminary anti-tumor activity...

St Louis, MOPHASE142 participantsLTZ Therapeutics, Inc.

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NCT07226934Recruiting

An AI-Generated, Personalized Question Prompt List Intervention for Patients With Hematologic Cancers

The goal of this study is to evaluate the feasibility and preliminary efficacy of an artificial intelligence (AI)-generated personalized question prompt list (a list of suggested questions to ask duri...

St Louis, MONA40 participantsWashington University School of Medicine

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NCT06687772Recruiting

CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant

A serious consequence of systemic diffuse large B-cell lymphoma (DLBCL) is secondary central nervous system (CNS) relapse, which occurs in approximately 5% of all patients. Many CNS relapses occur wit...

St Louis, MOPHASE236 participantsWashington University School of Medicine

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NCT04301076Recruiting

Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)

This phase I trial studies the side effects and best dose of lenalidomide when given together with usual combination chemotherapy (etoposide, prednisone, vincristine sulfate \[Oncovin\], cyclophospham...

St Louis, MOPHASE130 participantsNational Cancer Institute (NCI)

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NCT06672705Recruiting

Epcoritamab for the Treatment of Relapsed or Refractory Post Transplant Lymphoproliferative Disorders

This phase Ib trial tests the safety and effectiveness of epcoritamab in treating patients with post-transplant lymphoproliferative disorder (PTLD) that has come back after a period of improvement (re...

St Louis, MOPHASE126 participantsTimothy Voorhees

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NCT07052305Recruiting

NT-I7 (Efineptakin Alfa), a Long-acting Human IL-7, Post-Axicabtagene Ciloleucel or Post-Lisocabtagene Maraleucel in Subjects With Relapsed/Refractory Large B-cell Lymphoma

Diffuse large B-cell lymphoma is the most commonly occurring subtype of non-Hodgkin lymphoma, but treatment is often not curative, with as many as 50% of patients with adverse risk factors developing ...

St Louis, MOPHASE124 participantsWashington University School of Medicine

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NCT06390956Recruiting

Pirtobrutinib in Combination With Rituximab in Adults With Untreated Marginal Zone Lymphoma (PIONEER-MZL)

The purpose of this clinical trial is to learn if the drugs Pirtobrutinib and Rituximab are effective for the treatment of newly diagnosed marginal zone lymphoma....

St Louis, MOPHASE223 participantsUniversity of Utah

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About Lymphoma Clinical Trials in St Louis

Lymphoma is a cancer of the lymphatic system that affects infection-fighting cells called lymphocytes. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma. Treatment often includes chemotherapy, radiation, immunotherapy, and in some cases stem cell transplant.

There are currently 18 lymphoma clinical trials recruiting participants in St Louis, MO. These studies are seeking a combined 1,614 participants. Research is being sponsored by AstraZeneca, Ono Pharmaceutical Co., Ltd., Treeline Biosciences, Inc. and 12 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Lymphoma Clinical Trials in St Louis — FAQ

Are there lymphoma clinical trials in St Louis?

Yes, there are 18 lymphoma clinical trials currently recruiting in St Louis, MO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in St Louis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you about next steps.

Are clinical trials in St Louis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many St Louis studies also compensate for your time and travel.

What lymphoma treatments are being tested?

The 18 active trials in St Louis are testing new therapies including novel drugs, biologics, and treatment approaches for lymphoma.

Data updated July 19, 2026 from ClinicalTrials.gov