22 Osteogenesis Imperfecta Clinical Trials in St Louis, MO (2026)

Q: How do I join a clinical trial in St Louis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you.

Recruiting Osteogenesis Imperfecta Studies in St Louis

NCT07358078Recruiting

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

The purpose of this study is to: * Describe the clinical characteristics of adult patients with transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) treated with vutrisiran in routine cli...

St Louis, MO2,000 participantsAlnylam Pharmaceuticals

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NCT07223814Recruiting

Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

The current standard of care treatment for adult patients with acute myeloid leukemia (AML) consists of chemotherapy and, if indicated, donor stem cell transplantation. Bleximenib blocks the interact...

St Louis, MOPHASE3875 participantsStichting Hemato-Oncologie voor Volwassenen Nederland

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NCT05997810Recruiting

Parathyroid Tumor Clonal Status

To define the frequency of monoclonal-X and polyclonal-X tumors in hyperparathyroid disorders patients having PTX and to define the relationship between parathyroid tumor clonal status and multiple gl...

St Louis, MO839 participantsWashington University School of Medicine

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NCT05750498Recruiting

A-LiNK: Improving Outcomes in Autoimmune Liver Disease

The Autoimmune Liver disease Network for Kids (A-LiNK) is a multi-institutional group with the mission to deliver the best care to kids with pediatric autoimmune liver disease (AILD). This study will...

St Louis, MO800 participantsChildren's Hospital Medical Center, Cincinnati

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NCT07581002Recruiting

A Study to Assess Adverse Events and Change in Disease Activity When Intravenous (IV) Pivekimab Sunirine is Given in Combination With Oral Venetoclax and IV or Subcutaneous Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML)

Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow (the spongy tissue inside the ...

St Louis, MOPHASE2660 participantsAbbVie

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NCT07154823Recruiting

A Longitudinal Multi-Center Molecular Biomarker Discovery Registry for Patients With Hematologic Malignancies

The TEMPUS AQUARIUS Study is a non-interventional, longitudinal observational study focused on hematological malignancies. It will collect rich molecular (multi-omic) and clinical data from patient co...

St Louis, MO550 participantsTempus AI

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NCT07673380Recruiting

Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City

The sequential trial compares recovery and mHealth engagement outcomes among Black participants who participated in the mHealth intervention uMAT-R or uMAT-R + enhanced community engagement. The mHeal...

St Louis, MOPHASE2300 participantsWashington University School of Medicine

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NCT06465199Recruiting

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one that has not been approved by the U.S. Foo...

St Louis, MOPHASE1265 participantsMilton S. Hershey Medical Center

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NCT07695701Recruiting

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

The study aims to evaluate the effect of acoramidis on cardiac functional and structural improvement in participants with ATTR-CM....

St Louis, MOPHASE4150 participantsEidos Therapeutics, a BridgeBio company

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NCT07003100Recruiting

A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

This study is being done to assess mogamulizumab-associated rash in patients diagnosed with mycosis fungoides or sezary syndrome and treated with standard of care mogamulizumab. One of the most common...

St Louis, MO100 participantsCity of Hope Medical Center

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NCT05957367Recruiting

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

This is a Phase 1/2, multicenter, open-label (unless otherwise specified in a combination-specific module) study of inlexisertib in combination with anticancer therapies. Modules within the master pro...

St Louis, MOPHASE194 participantsDeciphera Pharmaceuticals, LLC

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NCT07081646Recruiting

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis....

St Louis, MOPHASE191 participantsAlexion Pharmaceuticals, Inc.

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NCT07062588Recruiting

Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN)

This study will determine the effect of treatment of AGA2115 in adults with Type I, III, or IV osteogenesis imperfecta versus placebo....

St Louis, MOPHASE280 participantsAngitia Incorporated Limited

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NCT04336644Recruiting

Continuous Versus Intermittent cARdiac Electrical moNitorinG

The purpose of this study is to validate the continuous patch monitoring system to evaluate cardiac arrhythmias in patients receiving drugs that can cause cardiac complications and compare the continu...

St Louis, MONA60 participantsWashington University School of Medicine

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NCT07406893Recruiting

Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan woun...

St Louis, MONA60 participantsSt. Louis University

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NCT06529731Recruiting

Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

This phase 2 study aims to confirm the efficacy seen in the prior phase 1 trial, and further contribute to this effort through the collection of leukemia cells pre- and post- in vivo IFN-γ therapy. As...

St Louis, MOPHASE257 participantsSawa Ito, MD

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NCT04557618Recruiting

Auricular VNS Following Subarachnoid Hemorrhage

This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following spontaneous subarachnoid hemorrhage....

St Louis, MONA50 participantsAnna Huguenard

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NCT07201558Recruiting

Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

This open-label, Phase I study will assess the safety and tolerability of surovatamig and characterise its PK and PD following subcutaneous administration to participants with RA or SLE....

St Louis, MOPHASE148 participantsAstraZeneca

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NCT07104331Recruiting

SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid Hemangioendothelioma

This is a non-randomized, open label, single arm Phase II trial with a two-stage design with histologically-confirmed metastatic and/or recurrent epithelioid hemangioendothelioma requiring systemic tr...

St Louis, MOPHASE241 participantsSarcoma Alliance for Research through Collaboration

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NCT07092514Recruiting

Lenvatinib 24 mg/Day Versus 10 mg/Day to Treat Symptomatic or Progressive Radioactive Iodine Resistant (RAIR) Differentiated Thyroid Cancer (DTC)

This open-label, randomized phase II trial evaluates the dose delivery, tolerance, and efficacy of two dosing regimens of lenvatinib among patients with radioactive iodine resistant (RAIR) differentia...

St Louis, MOPHASE234 participantsWashington University School of Medicine

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NCT06538181Recruiting

Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

VEXAS (vacuoles, E1 ubiqutin-activating enzyme, X-linked, autoinflammatory, somatic syndrome) is a recently described disorder with severe hematologic and rheumatologic manifestations caused by somati...

St Louis, MOPHASE115 participantsWashington University School of Medicine

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NCT07392970Recruiting

Motixafortide for MRD Sensitization in AML

This is a pilot phase I study evaluating the effect of motixafortide on determination of measurable residual disease (MRD) level in patients with acute myeloid leukemia (AML) who have completed induct...

St Louis, MOPHASE210 participantsWashington University School of Medicine

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About Osteogenesis Imperfecta Clinical Trials in St Louis

Osteogenesis imperfecta is a group of genetic disorders mainly affecting the bones, causing them to break easily, often from little or no apparent cause. It is caused by defects in collagen production. Treatment includes bisphosphonates, physical therapy, and surgical rodding.

There are currently 22 osteogenesis imperfecta clinical trials recruiting participants in St Louis, MO. These studies are seeking a combined 7,179 participants. Research is being sponsored by Alnylam Pharmaceuticals, Stichting Hemato-Oncologie voor Volwassenen Nederland, Washington University School of Medicine and 14 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Osteogenesis Imperfecta Clinical Trials in St Louis — FAQ

Are there osteogenesis imperfecta clinical trials in St Louis?

Yes, there are 22 osteogenesis imperfecta clinical trials currently recruiting in St Louis, MO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in St Louis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you about next steps.

Are clinical trials in St Louis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many St Louis studies also compensate for your time and travel.

What osteogenesis imperfecta treatments are being tested?

The 22 active trials in St Louis are testing new therapies including novel drugs, biologics, and treatment approaches for osteogenesis imperfecta.

Data updated October 12, 2026 from ClinicalTrials.gov