13 Melanoma Clinical Trials in Tampa, FL (2026)

Q: How do I join a clinical trial in Tampa?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Tampa research site will contact you.

Recruiting Melanoma Studies in Tampa

NCT07222995Recruiting

Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in FQHCs

The purpose of this study is to examine how different messages about risk of skin cancer can impact the uptake of skin cancer prevention activities....

Tampa, FLNA2,900 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT03567889Recruiting

Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients

The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of...

Tampa, FLPHASE3186 participantsPhilogen S.p.A.

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NCT06624644Recruiting

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

The goal of this clinical trial is to understand if a new drug called LNS8801 can safely treat patients with melanoma. The primary question to be answered is what is the average length of time during ...

Tampa, FLPHASE2135 participantsLinnaeus Therapeutics, Inc.

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NCT05538130Recruiting

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors....

Tampa, FLPHASE1124 participantsPfizer

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NCT06007690Recruiting

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melano...

Tampa, FLPHASE3100 participantsAura Biosciences

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NCT06295159Recruiting

Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma

The purpose of this study is to determine if neoadjuvant (treatment before surgery) immunotherapy treatment based on tumor biomarkers results in better participant outcomes. Immunotherapy is the treat...

Tampa, FLPHASE290 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT05361174Recruiting

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC)....

Tampa, FLPHASE153 participantsIovance Biotherapeutics, Inc.

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NCT04741997Recruiting

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

The purpose of this study is to assess rate of disease relapse and hazard rate of disease relapse after neoadjuvant therapy based on the statuses of pathologic complete response or non-pathologic comp...

Tampa, FLEARLY_PHASE150 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT06961357Recruiting

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

This is a phase I/II clinical trial of a single dose of CD40L-augmented TIL administered in patients with advanced melanoma (Cohort 1: Cutaneous acral melanoma, cutaneous non-acral melanoma, (n=26); C...

Tampa, FLPHASE136 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT06121180Recruiting

Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma

The goal of this clinical research study is to find out if Cemiplimab plus Ziv-Aflibercept is safe and effective in treating your condition of metastatic (spread to other parts of your body) uveal mel...

Tampa, FLPHASE232 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT04562129Recruiting

IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients

The purpose of this study is to find out if the administration of Interleukin-2 concurrently with ipilimumab followed by Nivolumab will result in improved anti-cancer activity and if it is effective f...

Tampa, FLPHASE229 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT04996823Recruiting

Axitinib + Ipilimumab in Advanced Melanoma

The goal of this clinical research study is to find out if taking axitinib with ipilimumab is effective in treating advanced melanoma....

Tampa, FLPHASE225 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT07276386Recruiting

Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma

This Phase 2 study evaluates the efficacy and safety of sequential treatment with percutaneous hepatic perfusion (PHP) using melphalan/HDS followed by tebentafusp in patients with metastatic uveal mel...

Tampa, FLPHASE218 participantsH. Lee Moffitt Cancer Center and Research Institute

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About Melanoma Clinical Trials in Tampa

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 13 melanoma clinical trials recruiting participants in Tampa, FL. These studies are seeking a combined 3,778 participants. Research is being sponsored by H. Lee Moffitt Cancer Center and Research Institute, Philogen S.p.A., Linnaeus Therapeutics, Inc. and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in Tampa — FAQ

Are there melanoma clinical trials in Tampa?

Yes, there are 13 melanoma clinical trials currently recruiting in Tampa, FL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Tampa?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Tampa research site will contact you about next steps.

Are clinical trials in Tampa free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Tampa studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 13 active trials in Tampa are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated July 18, 2026 from ClinicalTrials.gov