Charlestown, MANCT04400266Now EnrollingIRB Ready

Depression Following Traumatic Brain Injury Clinical Trial in Charlestown, MA

Access cutting-edge depression following traumatic brain injury treatment through this clinical trial at a research site in Charlestown. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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Expert Care in Charlestown

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related depression following traumatic brain injury treatment provided free

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Check if you qualify for this depression following traumatic brain injury clinical trial in Charlestown, MA

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Why Participate?

  • No-Cost Study Care

  • Local to Charlestown

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charlestown site if eligible
  4. 4Begin participation

About This Depression Following Traumatic Brain Injury Study in Charlestown

Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conducted a pilot clinical trial, which investigated the novel treatment combination of buspirone and melatonin (B+MEL) in outpatients with clinical depression. Compared to placebo, B+MEL was associated with a significant improvement in depressive symptoms. Depression following TBI may be different from c

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Patients with mild or moderate TBI will be included. To be included, a subject must meet the criteria below: 1. Non-penetrating mild or moderate traumatic brain injury that occurred 3 or more months prior to study entry (to minimize natural recovery from TBI) 2. Age: 18-64 years 3. Meeting any one of the following severity criteria, as documented in the patient's medical records: 1. Glasgow Coma Scale (GCS) score of 9-15 within 4 hours after injury 2. Loss of consciousness (LOC) \>1 minute and \<=24 hours 3. Post-traumatic amnesia (PTA) \< 7 days 4. English-speaking 5. Current DSM-5 diagnosis of Major Depressive Episode by medical record diagnosis 6. HAM-D-21 score of 18 or higher 7. Patients who are considered to be appropriate by their clinician and who are willing to be started on Buspirone and Melatonin for clinical purposes.

Exclusion Criteria

History of neurological disorder (e.g., stroke, epilepsy, multiple sclerosis, HIV, neurodegenerative

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charlestown?

Yes, this clinical trial (NCT04400266) has an active research site in Charlestown, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depression Following Traumatic Brain Injury Treatment Options in Charlestown, MA

If you're searching for depression following traumatic brain injury treatment options in Charlestown, MA, this clinical trial (NCT04400266) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charlestown research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depression following traumatic brain injury specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all depression following traumatic brain injury clinical trials near you to find additional studies recruiting in your area.

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