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A Study of Ranolazine in ALS

Sponsored by Swathy Chandrashekhar, MBBS

Quick Self-Assessment

See if you qualify and express your interest

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Current Status

Recruiting

Auto-verified from ClinicalTrials.gov

Verified Oct 28, 2025

Phase

Clinical Trial

Sponsor

Swathy Chandrashekhar, MBBS

Enrollment Target

72

Start Date

Apr 2025

๐Ÿ“Š
1 of 72 participants interested
1% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The purpose of this study is to evaluate safety, effect on cramps, function and quality of life of ranolazine versus placebo for the treatment of ALS.

Who Can Participate

Inclusion Criteria

18 years or older
Diagnosed with clinically definite, possible, probably, or lab-supported probable ALS per revised El Escorial criteria
Breathing assessment called forced vital capacity (FVC) greater than or equal to 50%.
Able to swallow pills at the start of the study and expected to for the length of the study.
If on ALS modifying medications must be on a stable dose at least 30 days.
Experiencing 4 or more cramps per week during a 2-week screening period.

Exclusion Criteria

Disease duration \< 5 years
Tracheostomy invasive ventilation, or noninvasive ventilation of more than 12 hours/day
Pregnant or lactating, adults unable to consent, and prisoners
Taking ranolazine or investigational drug or has received an investigational drug within 30 days (or 5 half-lives for drugs, whichever is longer) prior to screening
Medically uncontrolled comorbidities (heart, liver, kidney disease)
Baseline QTc interval prolongation \>450 ms for men/ \>47

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

72 participants

โšง

Gender

ALL

๐Ÿข

Sponsor

Swathy Chandrashekhar, MBBS

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

San Francisco

California

Location available
View San Francisco location page
RECRUITING

Jacksonville

Florida

Location available
View Jacksonville location page
RECRUITING

Fairway

Kansas

Location available
View Fairway location page
RECRUITING

Wichita

Kansas

Location available
View Wichita location page
RECRUITING

Columbia

Missouri

Location available
View Columbia location page
RECRUITING

Columbus

Ohio

Location available
View Columbus location page
NOT_YET_RECRUITING

Austin

Texas

Location available
View Austin location page

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Find More ALS Trials by City

Browse all als clinical trials in these cities โ€” not just this study.

Looking for ALS Treatment in San Francisco?

Join others in California exploring innovative treatment options through clinical research

ALS Treatment Options in San Francisco, California

If you're searching for ALS treatment in San Francisco, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in San Francisco, Jacksonville, Fairway and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with ALS. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 72 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for ALS?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for ALS

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This ALS Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06527222. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.