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NCT06785454RECRUITINGIRB Ready

A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension

Sponsored by Mineralys Therapeutics Inc.

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...
๐Ÿ“Š
1 of 40 participants interested
3% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The primary purpose of the study is to assess the effect of lorundrostat taken orally (po) once a day on the Apnea-Hypopnea Index (AHI) in participants with moderate to severe obstructive sleep apnea (OSA) and hypertension.

Who Can Participate

Inclusion Criteria

Body mass index (BMI) โ‰ฅ 27 kilograms per meter square (kg/m\^2) 2. Previously diagnosed with moderate-to-severe OSA 3. AHI โ‰ฅ15 events per hour (/hr) prior to Randomization 4. AOBP SBP of โ‰ฅ130 and less than or equal to (โ‰ค) 180 millimeter of mercury (mmHg) and AOBP diastolic blood pressure (DBP) โ‰ฅ60 and โ‰ค110 mmHg 5. Participants on CPAP or PAP therapy are eligible provided they are on PAP for โ‰ฅ4 hours per night (documented) and for at least 3 months prior to the study enrollment (documented) 6. Participants not currently on PAP therapy, and not anticipated to start PAP for the duration of the study 7. Fertile male and female participants of childbearing potential, and their partners, must agree to use protocol-defined methods of highly effective contraception from the Screening Visit until 28 days after the last dose of study drug

Exclusion Criteria

Type 2 diabetes mellitus (T2DM) with a glycosylated hemoglobin (HbA1c) greater than (\>) 9 percent (%) (\>74.9

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

40 participants

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Age Range

18 Years - 75 Years

โšง

Gender

ALL

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Sponsor

Mineralys Therapeutics Inc.

Study Locations

Choose your preferred location or select flexible during enrollment

Unknown

Tuscaloosa

Alabama

Location available
View Tuscaloosa location page
Unknown

Chandler

Arizona

Location available
View Chandler location page
Unknown

Little Rock

Arkansas

Location available
View Little Rock location page
Unknown

Anaheim

California

Location available
View Anaheim location page
Unknown

Carlsbad

California

Location available
View Carlsbad location page
Unknown

Riverside

California

Location available
View Riverside location page
Unknown

Denver

Colorado

Location available
View Denver location page
Unknown

Cutler Bay

Florida

Location available
View Cutler Bay location page
Unknown

Daytona Beach

Florida

Location available
View Daytona Beach location page

๐Ÿ“ And 18 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Obstructive Sleep Apnea Treatment in Tuscaloosa?

Join others in Alabama exploring innovative treatment options through clinical research

Obstructive Sleep Apnea Treatment Options in Tuscaloosa, Alabama

If you're searching for Obstructive Sleep Apnea treatment in Tuscaloosa, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Tuscaloosa, Chandler, Little Rock and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Obstructive Sleep Apnea. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Alabama
Now Enrolling
Up to 40 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Obstructive Sleep Apnea?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Obstructive Sleep Apnea

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Obstructive Sleep Apnea Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06785454. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.