NCT07380412 · Outliers, Inc.
A Study to Evaluate the Effects of a Supplement on the Side Effects Associated With Stimulant Medications
What this study is about
This is a hybrid, two-treatment group$1, triple-blind, compared against an inactive treatment, randomly assigned clinical trial evaluating the effectiveness of the Stasis supplement on reducing oxidative stress, cortisol levels, and side effects associated with stimulant medications used for ADHD over a three-month period in adults.
View original scientific description
This is a hybrid, two-arm, triple-blind, placebo-controlled, randomized clinical trial evaluating the efficacy of the Stasis supplement on reducing oxidative stress, cortisol levels, and side effects associated with stimulant medications used for ADHD over a three-month period in adults.
Interventions
DIETARY_SUPPLEMENT
Stasis Daytime and Nighttime
Daytime taken with stimulant medication and food. Nighttime taken 30 minutes before bedtime on an empty stomach.
DIETARY_SUPPLEMENT
Placebo
Matched placebo product in taste and appearance.
Primary outcome measures
Change in oxidative stress and cortisol levels as measured by hs-CRP, 8-OHdG
Time frame: Baseline and Month 3
Measurement of oxidative stress and cortisol levels will be assessed using the following validated biomarkers: hs-CRP and serum cortisol from blood samples 8-hydroxy-2'-deoxyguanosine (8-OHdG) from urine samples
Change in cortisol levels
Time frame: Baseline and Month 3
Serum cortisol concentration measured via blood draw.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Aged 18-55 years
- Currently prescribed stimulant medication for ADHD
- Experiencing: sleep difficulty, irritability, anxiety, brain fog
- Stable medication dose ≥3 months
- Healthy with no uncontrolled chronic conditions
- Stable on supplements ≥3 months if applicable
- US resident
- Willing to maintain current habits
Exclusion criteria
- Chronic conditions (e.g. cancer, mental illness)
- Use of psychiatric medications besides stimulants
- Pregnancy, breastfeeding, thyroid, liver, kidney conditions
- Recent smokers or heavy alcohol use
- Night shift workers
- Participation in other clinical trials
- Allergies to product ingredients
Where
- Las Vegas, Nevada
Collaborators
Citruslabs
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 2, 2026 · Source of record for eligibility and locations