Is NCT03937817 recruiting in Bethesda, MD?

Yes, NCT03937817 is currently recruiting participants at its Bethesda, MD location. This alpha and beta thalassemia clinical trial is actively enrolling qualified participants.

How do I join the alpha and beta thalassemia clinical trial in Bethesda?

To join this clinical trial in Bethesda, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Bethesda clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Alpha and Beta Thalassemia Clinical Trial in Bethesda, MD

About This Alpha and Beta Thalassemia Study in Bethesda

Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders. To do this, they need to collect biological samples from people with blood disorders. They also need to collect samples from healthy people. Objective: To collect samples to use for research on blood disorders. Eligibility: People ages 18-70 who have blood disorders. Healthy volunteers without blood disorders are also needed. Design: Participants will be screened with a medical history, physical exam, and blood and urine tests. Participants will give one or more samples. They will give them over 5 years. They can choose not to give any of the samples: Saliva: Participants will spit into a tube. They may also have the inside of their mouth swabbed. Urine: Participants will urinate into a cup. Blood and blood waste products: Blood will be taken through a needle in the participant s arm. Fat samples: An area on the participant s belly or buttock will be numbed. A small cut will be made into the skin and a small piece of fat removed. Mucus and cells from the lungs: The participant will be sedated. A flexible tube will be inserted through the nose or mouth into the lung airways. These participants will also have a physical exam, chest x-ray, and heart tests after the procedure.

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Who Can Participate

Inclusion Criteria

Aged 18-70 years.

Able to provide informed consent.

Willing to allow biological samples to be stored for future research.

Willing to provide one or more of the following tissues: saliva, urine, blood, blood waste products, adipose tissue, bronchial brushing, and/or BAL samples.

Willing to allow genetic testing on collected biological samples. PARTICIPANT

Exclusion Criteria

Positive testing for hepatitis B virus, hepatitis C virus, or HIV (as determined by serum screening tests or relevant viral quantitative studies.)

Any condition that requires active medical intervention or monitoring to avert serious danger to the individual s health or wellbeing.

Any condition that, in the opinion of the PI, contraindicates participation in this study.

Additional Exclusion Criteria for Individuals Giving Blood for Research 1\. Hemoglobin \< 10 g/dL for healthy female volunteers, \< 12 g/dL for healthy male volunteers, or \< 6 g/dL for participants with sickle cell disease or other chronic anemias. -Additional Exclusion Criteria for Adipose Tissue Biopsy Individuals meeting any of the following criteria will be excluded from undergoing adipose tissue biopsy. If the participant no longer meets any of these criteria at a later time, then they will be allowed to undergo this procedure.

Currently taking anticoagulation medication.

Platelets \< 100,000/microL.

History of keloid formation (or irregular fibrous tissue formed at the site of a scar or injury).

History of adverse reactions to lidocaine or other local anesthetics.

Any condition that, in the opinion of the PI, contraindicates this procedure. Use of aspirin (or acetylsalicylic acid) and nonsteroidal anti-inflammatory drugs (NSAIDs) are permitted. -Additional Exclusion Criteria for Bronchoscopy Individuals meeting any of the following criteria will be excluded from undergoing bronchoscopy. If the participant no longer meets any of these criteria at a later time, then they will be allowed to undergo this procedure.

Prothrombin time (PT) \> 1 second above the upper limit of normal (ULN) or international normalized ratio \> 1.3.

Partial thromboplastin time (PTT) \> 1 second above ULN.

Platelets \< 150,000/microL.

Currently taking anticoagulation medication.

Use of aspirin within 2 weeks of the bronchoscopy or NSAIDs within 2 days of the bronchoscopy.

Diagnosis of a pulmonary disorder (eg, asthma, chronic bronchitis, cystic fibrosis, or bronchiectasis).

Respiratory tract infection within the last 4 weeks.

History of adverse reactions to systemic and/or local anesthetics that will be used for this procedure.

History of cigarette smoking within the past 3 months.

History of chronic opioid use.

History of drug or alcohol abuse.

Post-bronchodilator forced expiratory volume in 1 second (FEV1) \< 40% of predicted or pre-bronchodilator FEV1 \< 35% of predicted.

Active bronchospasm on physical examination.

History of lidocaine allergy.

Any condition that, in the opinion of the PI, contraindicates this procedure. Co-enrollment guidelines: Participants may be co-enrolled in other studies. However, the PI must be notified of co-enrollment.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Bethesda?

Yes, this clinical trial (NCT03937817) has an active research site in Bethesda, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alpha and Beta Thalassemia Treatment Options in Bethesda, MD

If you're searching for alpha and beta thalassemia treatment options in Bethesda, MD, this clinical trial (NCT03937817) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Bethesda research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alpha and beta thalassemia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alpha and beta thalassemia clinical trials near you to find additional studies recruiting in your area.

Alpha and Beta Thalassemia Clinical Trial in Bethesda, MD

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