Boston, MANCT05797857Now EnrollingIRB Ready

Amyloid Cardiomyopathy Clinical Trial in Boston, MA

Access cutting-edge amyloid cardiomyopathy treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Brigham and Women's Hospital

Quick Self-Assessment

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Expert Care in Boston

Access amyloid cardiomyopathy specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related amyloid cardiomyopathy treatment provided free

Apply for This Boston Location

Check if you qualify for this amyloid cardiomyopathy clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Amyloid Cardiomyopathy Study in Boston

Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patients on optimal treatment for transthyretin cardiac amyloidosis. This is a vital next step to improve functional capacity and quality of life of people suffering from transthyretin cardiac amyloidosis.

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

Diagnosis and typing of ATTR-CM by endomyocardial biopsy or by Grade 2 or Grade 3 pyrophosphate (PYP) positivity (exception: nonamyloid control arm in aim 1).
Diagnosis of heart failure, with prior or current need of diuretics and increased N-terminal prohormone B-natureitic peptide (BNP) (≥450 pg/ml).
Peak VO2 \<80% predicted, indicating impaired aerobic capacity (for aim 2 only).
Taking tafamidis (for aim 2 only)
Able to walk 4 meters (with or without the use of an assistive device) and independent with basic activities of daily living at the time of enrolment.
Adequate clinical stability has been achieved in the judgment of the investigator to allow participation in study assessments and the intervention.
Signed informed consent document indicating that the patient understands the purpose of and procedures required for the study and is willing to participate in the study.

Exclusion Criteria

Acute myocardial infarction (Note: given that cardiac biomarkers such as troponin are frequently elevated in ATTR-CM patients, the diagnosis of acute myocardial infarction should be based on clinical diagnosis, not biomarkers alone)
\>70% obstructive coronary artery disease
Severe aortic valve stenosis
Already actively participating in formal, facility-based cardiac exercise
Already engaging in regular moderate to vigorous exercise conditioning defined as \> 30 minutes per day, ≥ twice per week consistently during the previous 6 weeks
Ventricular assist device
Light chain amyloidosis or other form of non-ATTR amyloidosis
Advanced chronic kidney disease defined as estimated glomerular filtration rate \<20 mL/min/1.73m2
Any organ transplantation
Terminal illness other than HF with life expectancy \< 1 year
Pacemaker or implantable cardioverter-defibrillato (ICD) with heart rate limits \< expected heart rates for exercise and unable to be reprogrammed
Neuropathy due to transthyretin (TTR) mutation
Impairment from stroke, injury or other medical disorder that precludes participation in the intervention
Abnormal cardiopulmonary exercise testing (CPET) finding that requires further investigation and management
Dementia that precludes ability to participate in exercise and follow study protocols
High risk for non-adherence as determined by screening evaluation
Inability or unwillingness to comply with the study requirements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05797857) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Amyloid Cardiomyopathy Treatment Options in Boston, MA

If you're searching for amyloid cardiomyopathy treatment options in Boston, MA, this clinical trial (NCT05797857) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced amyloid cardiomyopathy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all amyloid cardiomyopathy clinical trials near you to find additional studies recruiting in your area.

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