Ann Arbor, MINCT04566991Now EnrollingIRB Ready

Aneurysmal Subarachnoid Hemorrhage Clinical Trial in Ann Arbor, MI

Access cutting-edge aneurysmal subarachnoid hemorrhage treatment through this clinical trial at a research site in Ann Arbor. Study-provided care at no cost to qualified participants.

Sponsored by Aditya S. Pandey, MD

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Expert Care in Ann Arbor

Access aneurysmal subarachnoid hemorrhage specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related aneurysmal subarachnoid hemorrhage treatment provided free

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Check if you qualify for this aneurysmal subarachnoid hemorrhage clinical trial in Ann Arbor, MI

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Why Participate?

  • No-Cost Study Care

  • Local to Ann Arbor

    Convenient for MI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Ann Arbor site if eligible
  4. 4Begin participation

About This Aneurysmal Subarachnoid Hemorrhage Study in Ann Arbor

Aneurysmal subarachnoid hemorrhage (aSAH) has a high incidence of mortality and significant morbidity, with mortality exceeding 30% in the first two days.The initial injury is related to increasing intracranial pressure, cerebral edema, and neuronal injuries associated with the release of iron. Iron has been shown to increase the incidence of cerebral edema, ischemia, and formation of hydrocephalus. Deferoxamine mesylate (DFO), a hydrophilic chelator, creates a stable complex with free iron thus preventing the formation of iron related free radicals. This trial will evaluate the safety and efficacy of clinical deferoxamine for the treatment of aSAH for patients that are admitted to the hospital at the University of Michigan. Eligible participants will be enrolled and randomized to 1 of 2 doses of Deferoxamine or placebo (saline). Information regarding the patients will be collected and followed for up to 6 months post discharge.

Sponsor: Aditya S. Pandey, MD

Who Can Participate

Inclusion Criteria

Aneurysmal SAH confirmed with vascular imaging
Aneurysm treated with endovascular or microsurgical intervention
Hunt-Hess ≤ 4
Modified Fisher Grade I-IV
Glasgow Coma Scale (GCS) ≥ 7 following External Ventricular Drain (EVD) placement if indicated
First dose of drug can be administered within 24 hours of symptom onset
Functional independence prior to SAH, Modified Rankin Scale (mRS) ≤ 1
Informed consent obtained by patient or legal authorized representative (LAR)

Exclusion Criteria

Previous hypersensitivity to or treatment with deferoxamine
Presence of giant aneurysm (\>25 mm in size)
Known severe iron deficiency anemia, Hemoglobin (Hgb) g/dl ≤ 7 or transfusion dependent
Irreversibly impaired brainstem function
Abnormal renal function, Serum Creatinine\> 2 mg/dL
Pre-existing severe disability, mRS ≥ 2
Coagulopathy, including use of anti-platelet or anticoagulant drugs
Known severe hearing loss
Chronic pulmonary disease that limits basic activities of daily living at baseline, or requires the use of home oxygen.
Acute pulmonary disease with the need for any of the following - in a 72 hour period prior to enrollment: \>4L/minute nasal cannula (or equivalent O2 delivery via face mask/ tent), heated-high flow nasal cannula, noninvasive positive pressure ventilation, and in intubated patients FiO2\>45% or positive end-expiratory pressure (PEEP) \> 8cmH2O. This does not include the use of supplemental oxygen in any form for pre-oxygenation, apneic oxygenation, or peri-procedural support alone.
Taking iron supplements containing \> 325 mg of ferrous iron
Pregnancy or nursing
Life expectancy less than 90 days due to co-morbidities
Concurrent participation in another research protocol for investigation of another experimental therapy, though observational studies are allowed
Prior history of hepatic dysfunction
Known cytopenia (platelets \< 50,000, Absolute neutrophil count \< 500)
Current use of prochlorperazine
History of severe psychiatric disorder

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Ann Arbor?

Yes, this clinical trial (NCT04566991) has an active research site in Ann Arbor, MI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Aneurysmal Subarachnoid Hemorrhage Treatment Options in Ann Arbor, MI

If you're searching for aneurysmal subarachnoid hemorrhage treatment options in Ann Arbor, MI, this clinical trial (NCT04566991) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Ann Arbor research site is actively enrolling participants for this clinical trial. You'll receive care from experienced aneurysmal subarachnoid hemorrhage specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all aneurysmal subarachnoid hemorrhage clinical trials near you to find additional studies recruiting in your area.

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