NCT07890610 · Children's Hospital of Philadelphia
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
(PEDICA)
What this study is about
This is a forward-looking, observational, multi-center group of participants study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA).
View original scientific description
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.
Primary outcome measures
Return of Spontaneous Circulation (ROSC) lasting 20 minutes
Time frame: Duration of CPR event through 20 minutes after CPR
Sustained return of ROSC ≥20 minutes
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Arrest in an ICU
- Patients received chest compressions for at least 1 minute
Exclusion criteria
- Lack of commitment to aggressive therapies (e.g., CPR performed as part of end-of-life care)
- Brain death determination prior to CPR
- Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes)
- Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
Where
- Orange, California
- Stanford, California
- Denver, Colorado
- Wilmington, Delaware
- Atlanta, Georgia
- Chicago, Illinois
- Indianapolis, Indiana
- Iowa City, Iowa
- Boston, Massachusetts
- St Louis, Missouri
- New Hyde Park, New York
- New York, New York
And 9 more locations — see the full list below.
Collaborators
National Heart, Lung, and Blood Institute (NHLBI), University of Utah, Villanova University
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 22, 2026 · Source of record for eligibility and locations