NCT05881863 · University of Minnesota
To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation
What this study is about
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation).
View original scientific description
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the "laser mode" is activated on the Monsoon jet ventilator. Ventilation is continued during "laser mode.
Interventions
OTHER
No intervention
This is an observational study
Primary outcome measures
Time in seconds to AiO2 from 90 to 40%
Time frame: baseline
Time in seconds to AiO2 from 90 to 40% after activating laser mode on the monsoon jet ventilator.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.
- 18 years or older
- Need rigid bronchoscopy as pre-determined by the interventional pulmonologist
Exclusion criteria
- Refusal to sign consent
- Pregnant patients
- Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm
- Respiratory instability defined as SpO2\<90% with \>90% supplemental oxygen.
- Ineligible for rigid bronchoscopic intubation
- Latex allergy
- Evidence of fistulous airway
- Active Bronchopleural fistula
Where
- Minneapolis, Minnesota
Related conditions & keywords
Frequently asked questions
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Data: ClinicalTrials.gov · synced Jan 7, 2026 · Source of record for eligibility and locations