Chapel Hill, NCNCT06057714Now EnrollingIRB Ready

Cystic Fibrosis Clinical Trial in Chapel Hill, NC

Access cutting-edge cystic fibrosis treatment through this clinical trial at a research site in Chapel Hill. Study-provided care at no cost to qualified participants.

Sponsored by University of North Carolina, Chapel Hill

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Expert Care in Chapel Hill

Access cystic fibrosis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related cystic fibrosis treatment provided free

Apply for This Chapel Hill Location

Check if you qualify for this cystic fibrosis clinical trial in Chapel Hill, NC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Chapel Hill

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Chapel Hill site if eligible
  4. 4Begin participation

About This Cystic Fibrosis Study in Chapel Hill

The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measures to lung function assessed by spirometry and multiple breath nitrogen washout. This study also looks at how these measures change in response to a pulmonary exacerbation and treatment (if applicable). Over the span of a year, participants would be asked to complete 3-5 visits to the University of North Carolina at Chapel Hill (UNC). with each lasting up to 4 hours. If participants do not have a pulmonary exacerbation during the year they would be asked to complete 3 visits (one at enrollment, a second roughly 2 weeks later, and the third approximately a year later). If participants do experience a CF pulmonary exacerbation they would complete 5 visits (Visit 1, Visit 2, two exacerbation visits with one before treatment and the other after, and Visit 3 at one year after Visit 1). Only one exacerbation per participant will be tracked. Participants are eligible for this study if they are 18 years old or older, have Cystic Fibrosis (CF) with mild lung disease (FEV1 \>/= 60%), and can undergo an MRI. There are no known benefits for participating in this study.

Sponsor: University of North Carolina, Chapel Hill

Who Can Participate

Inclusion Criteria

Subjects must be ≥18 years of age
Non-smokers (\<10 pack/year history and no active smoking in the past year)
Diagnosis of cystic fibrosis via standard sweat chloride/phenotypic features/genotyping
No use of supplemental oxygen
Stable lung function (within 10% of personal best in the last 6 months) with no pulmonary exacerbations in the past 4 weeks and baseline FEV1≥60% of predicted
Evidence of a personally signed and dated consent indicating that the subject has been informed of all pertinent aspects of the trial
Subjects must be willing and able to comply with scheduled visits and other trial procedures

Exclusion Criteria

Subjects presenting with any of the following will not be included in the trial:
Active or past smokers or vapers with less than 1 year since quitting or \>10 pack-year smoking history
Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications including
Occupation (past or present) of machinist, welder, or grinder;
Injury to the eye involving a metallic object
Injury to the body by a metallic object (bullet, bullet ball, shrapnel)
Presence of a cardiac pacemaker or defibrillator
Presence of aneurysm clips
Presence of carotid artery vascular clamp
Presence of neurostimulator
Presence of insulin or infusion pump
Presence of implanted drug infusion device that is not known to be MRI compatible (i.e., was placed outside of UNC or is older than 10 years)
Bone growth or fusion simulator
Presence of cochlear, otologic or ear implant
Any type of prosthesis (eye, penile, etc.)
Artificial limb or joint
Non-removable electrodes (on body, head or brain)
Intravascular stents, filters or coils
Shunt (spinal or intraventricular)
Swan-Ganz catheter
Any implant held in place by a magnet
Transdermal delivery system (e.g. Nitro)
An intrauterine device or diaphragm that is not MRI compatible
Tattooed makeup (eyeliner, lips, etc.) or tattoos covering \>25% of body surface area
Body piercings (must be removed before MRI)
Any metal fragments
Internal pacing wires
Metal or wire mesh implants
Hearing aid (remove before MRI) aa. Dentures (remove before MRI) bb. Claustrophobia
Unable to tolerate inhalation of gas mixture
Presence of facial hair that may interfere with the fit of the mask (and unwillingness to shave prior to each MRI)
Any changes in medications that may affect CF lung disease in the past 28 days, including any experimental therapies
Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
Pregnancy; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chapel Hill?

Yes, this clinical trial (NCT06057714) has an active research site in Chapel Hill, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Cystic Fibrosis Treatment Options in Chapel Hill, NC

If you're searching for cystic fibrosis treatment options in Chapel Hill, NC, this clinical trial (NCT06057714) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chapel Hill research site is actively enrolling participants for this clinical trial. You'll receive care from experienced cystic fibrosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all cystic fibrosis clinical trials near you to find additional studies recruiting in your area.

More Cystic Fibrosis Trials in Chapel Hill, NC

See all cystic fibrosis clinical trials recruiting in Chapel Hill — not just this study.

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