NCT07510620 · Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists
Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses
What this study is about
This research study is to see if using Lacrifill is safe, easy to use, and helpful for people who wear contact lenses but can't wear them comfortably for long. Specifically, the study aims to determine whether regular use of Lacrifill over a 2-3 month period can help people wear their contacts longer without discomfort and reduce signs and symptoms of dry eye.
View original scientific description
This research study is to see if using Lacrifill is safe, easy to use, and helpful for people who wear contact lenses but can't wear them comfortably for long. Specifically, the study aims to determine whether regular use of Lacrifill over a 2-3 month period can help people wear their contacts longer without discomfort and reduce signs and symptoms of dry eye.
Interventions
DRUG
Lacrifill
Lacrifill is a cross-linked hyaluronic acid derivative that temporarily blocks tear drainage, allowing patients eyed to be bathed in their own natural tears.
Primary outcome measures
Dry eye signs
Time frame: 2-3 months
To asses the effect of Lacrifill.
Dry Eye Symptoms
Time frame: 2-3 Months
To asses the effect of Lacrifill.
Contact Lens Tolerability
Time frame: 2-3 Months
To asses the effect of Lacrifill.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- \>21 years of age
- Contact lens wearer
- Previous Dry Eye Treatment
- Be on a stable dose of antihistamines/Birth Control Medication and Lifitegrast and cyclosporine.
- Schrimers Anesthetized less than or equal to 10
- CLDEQ-8 greater than or equal to 12
- Corneal Staining NEI grading scale greater than or equal to 1
Exclusion criteria
- Known allergy to Hyaluronic Acid
- Current topical ophthalmic drops other than dry eye treatment
- Uncontrolled Diabetes
- Diabetic Retinopathy
- Pregnancy or Lactating
- Corneal Surgery (except Refractive)
- Corneal Scars
- Keratoconus
- Ocular Herpetic Keratitis
Where
- Kingston, Pennsylvania
Collaborators
Nordic Pharma, USA
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 3, 2026 · Source of record for eligibility and locations