Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Dry Eye Clinical Trials
Dry Eye clinical trials are recruiting across 38 cities. Here are the cities with the most active studies:
Dry Eye Trial Phases
18 research organizations are sponsoring dry eye trials.
About Dry Eye
Dry eye disease is a common condition that occurs when tears are unable to provide adequate lubrication for the eyes. It affects millions of people and can cause discomfort and vision problems. Treatment includes artificial tears, prescription eye drops, and procedures to conserve tears.
Clinical trials are advancing new treatments for dry eye. Currently, 21 studies are recruiting a combined 1,961 participants across the United States. Research is being conducted by 18 organizations including Dompé Farmaceutici S.p.A, Indiana University, Vanda Pharmaceuticals and 15 others.
2026 Dry Eye Research Landscape
As of July 2026, the dry eye clinical trial landscape includes 21 actively recruiting studies across 38 cities in the United States. These studies are collectively seeking 1,961 participants, with an average enrollment target of 93 per study.
The research spans multiple phases of development: 9 studies are in PHASE4, 4 studies are in NA, 3 studies are in PHASE2, 1 study is in PHASE3, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some dry eye treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 18 different organizations, including Dompé Farmaceutici S.p.A, Indiana University, Vanda Pharmaceuticals, Oculis, University of Maryland, Baltimore, and 13 others. The large number of sponsors reflects significant research interest and investment in dry eye treatment advancement.
Geographically, dry eye trials are most concentrated in Newport Beach, California (4 trials); Memphis, Tennessee (4 trials); Sioux Falls, South Dakota (3 trials); Glendale, California (2 trials); Murrieta, California (2 trials) and 7 other cities.
Featured Dry Eye Studies
Highlighted recruiting studies for dry eye, selected by enrollment size and research scope.
An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease
This is a Phase 2, randomized, multicenter, double masked, vehicle controlled, parallel group study to evaluate the efficacy and safety of DFL24498 topical ophthalmic solution versus vehicle in participants with dry eye disease. Approximately 417 participants aged 18 years or older who meet all eligibility criteria will be enrolled at study sites in the US. The study duration will be up to 16 week...
SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease
This is a prospective, randomized, double-masked, multi-site clinical trial designed to compare the efficacy of SYSTANE® PRO (Alcon Laboratories, Inc.) to MIEBO™ (Bausch + Lomb) in treating symptoms of evaporative dry eye disease (DED). The primary goal is to determine whether SYSTANE® PRO is non-inferior to MIEBO™ after one month of treatment, based on change in Ocular Surface Disease Index (OSDI...
An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of VSJ-110 compared to placebo in the treatment of dry eye.
Frequently Asked Questions About Dry Eye Clinical Trials
Are there dry eye clinical trials near me?
Yes, there are 21 dry eye clinical trials currently recruiting across 38+ cities in the United States, including Newport Beach, California; Memphis, Tennessee; Sioux Falls, South Dakota. Browse the studies above to find one at a location convenient for you.
How do I join a dry eye clinical trial?
To join a dry eye clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are dry eye clinical trials free?
Yes, participation in dry eye clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of dry eye treatments are being studied?
Current dry eye clinical trials are testing a range of approaches across PHASE4 (9 studies), NA (4 studies), PHASE2 (3 studies), PHASE3 (1 study), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 18 research organizations.
Is it safe to participate in dry eye clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov