Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant...
Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction
This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT)....
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowerin...
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
This is a randomized, double-blind, two-treatment, single-period, parallel design, multiple dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical endpoint in subje...
A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma
Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab interno ...
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02...
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participant...
Retinal Blood Flow and Autoregulation
The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma....
Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma
Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab externo ...
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
The purpose of this research study is to assess the ability of AMDX- 2011P to identify amyloid deposits in the retina of participants with Primary Open Angle Glaucoma (POAG)....
Top Cities for Glaucoma Clinical Trials
Glaucoma clinical trials are recruiting across 47 cities. Here are the cities with the most active studies:
About Glaucoma
Glaucoma is a group of eye conditions that damage the optic nerve, often due to abnormally high eye pressure, and is a leading cause of irreversible blindness. Open-angle glaucoma is the most common form. Treatment includes eye drops, laser treatment, and surgery to lower eye pressure.
Clinical trials are advancing new treatments for glaucoma. Currently, 10 studies are recruiting a combined 2,029 participants across the United States. Research is being conducted by 8 organizations including Glaukos Corporation, Alcon Research, Columbia University and 5 others.
2026 Glaucoma Research Landscape
As of March 2026, the glaucoma clinical trial landscape includes 10 actively recruiting studies across 47 cities in the United States. These studies are collectively seeking 2,029 participants, with an average enrollment target of 203 per study.
Research is being led by 8 different organizations, including Glaukos Corporation, Alcon Research, Columbia University, Amneal Pharmaceuticals, LLC, AbbVie, and 3 others.
Geographically, glaucoma trials are most concentrated in Newport Beach, California (4 trials); Glendale, Arizona (3 trials); Baltimore, Maryland (3 trials); Oklahoma City, Oklahoma (2 trials); Phoenix, Arizona (2 trials) and 7 other cities.
Featured Glaucoma Studies
Highlighted recruiting studies for glaucoma, selected by enrollment size and research scope.
Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction
This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowering glaucoma medications are used to treat glaucoma. A total of up to 188 participants will be enrolled and randomized 1:1 to receive N\&P or placebo for 87 weeks (20 months). Participants will be foll...
Frequently Asked Questions About Glaucoma Clinical Trials
Are there glaucoma clinical trials near me?
Yes, there are 10 glaucoma clinical trials currently recruiting across 47+ cities in the United States, including Newport Beach, California; Glendale, Arizona; Baltimore, Maryland. Browse the studies above to find one at a location convenient for you.
How do I join a glaucoma clinical trial?
To join a glaucoma clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are glaucoma clinical trials free?
Yes, participation in glaucoma clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of glaucoma treatments are being studied?
Current glaucoma clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 8 research organizations.
Is it safe to participate in glaucoma clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov