Baltimore, MDNCT03400826Now EnrollingIRB Ready

Fibroid Uterus Clinical Trial in Baltimore, MD

Access cutting-edge fibroid uterus treatment through this clinical trial at a research site in Baltimore. Study-provided care at no cost to qualified participants.

Sponsored by Johns Hopkins University

Quick Self-Assessment

See if you qualify for this Baltimore location

Preparing your pre-screening questions…

Expert Care in Baltimore

Access fibroid uterus specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related fibroid uterus treatment provided free

Apply for This Baltimore Location

Check if you qualify for this fibroid uterus clinical trial in Baltimore, MD

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Baltimore

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Baltimore site if eligible
  4. 4Begin participation

About This Fibroid Uterus Study in Baltimore

The study aims to study the effect of simvastatin on the size of uterine fibroids.

Sponsor: Johns Hopkins University

Who Can Participate

Inclusion Criteria

Signed informed written consent.
Gender: female.
Age: 18-55 years at time of signing consent.
BMI of subjects: \< 45 kg/m2.
Uterine fibroids:
Diagnosed by ultrasound (MRI will be used only if ultrasound is inconclusive).
Number: any number of fibroids.
Location: submucosal or intramural.
At least one fibroid of diameter \> 3cm.
Symptoms: one or more of the following symptoms of heavy menstrual bleeding (HMB), defined as: Experienced cyclic (22 to 35 days) abnormal uterine bleeding (heavy or prolonged) in at least 3 of the last 6 menstrual periods, including menstrual bleeding lasting 5 or more days or heavy bleeding per participant recall. Examples of heavy bleeding may include, but are not limited to the following:
Requires the use of double protection to manage menstrual bleeding.
Menstrual bleeding accompanied by the sensation of "gushing" or "flooding".
Saturates more than 1 tampon or sanitary pad per hour for 3 or more consecutive hours.
Regularly needs to change the tampon or sanitary pad at night or regularly soils bedclothes.
Heavy bleeding that affects work, school, or social activities.
Pelvic pain/ pressure likely caused by fibroids.
Plan for surgery (hysterectomy or myomectomy).
Normal Pap smear within the last year.
Use of contraception during study such as non-hormonal oral contraceptives, intrauterine devices (IUD)/ intrauterine systems (IUS), barrier contraceptives, abstinence or sterilization.

Exclusion Criteria

Pregnancy or lactation.
Previous or current uterine, cervical or ovarian cancer.
Current endometrial hyperplasia or history of atypical endometrial hyperplasia. Endometrial biopsy will be done during screening (if not done within last 12 months).
Suspicion of leiomyosarcoma.
Recent rapid growth of fibroids (i.e. doubling in size within 1-6 months period).
Unevaluated gynecologic abnormalities (unexplained vaginal bleeding, cervical dysplasia, or abnormal adnexal/ovarian mass).
Menopausal status.
Surgery is urgently indicated (\< 3 months) for medical or social reasons.
Hemoglobin ≤ 6 g/dL.
Currently enrolled in another investigational study.
Mental condition or other barrier preventing informed written consent.
Allergy or hypersensitivity to simvastatin.
Current use of simvastatin or other drugs of the same class.
Concomitant administration of strong CYP3A4 inhibitors including itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, boceprevir, telaprevir, nefazodone, and cobicistat-containing products.
Concomitant administration of gemfibrozil, cyclosporine, or danazol, verapamil, diltiazem, amiodarone, diltiazem, dronedarone, amlodipine, ranolazine, lomitapide, and grapefruit juice.
Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels.( elevation of aspartate transaminase and/or alanine transaminase \> 2 s.d. above the normal range at screening visit)
Known increased risk or diagnosis of a myopathy.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Baltimore?

Yes, this clinical trial (NCT03400826) has an active research site in Baltimore, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Fibroid Uterus Treatment Options in Baltimore, MD

If you're searching for fibroid uterus treatment options in Baltimore, MD, this clinical trial (NCT03400826) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Baltimore research site is actively enrolling participants for this clinical trial. You'll receive care from experienced fibroid uterus specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all fibroid uterus clinical trials near you to find additional studies recruiting in your area.

More Fibromyalgia Trials in Baltimore, MD

See all fibromyalgia clinical trials recruiting in Baltimore — not just this study.

Browse Fibromyalgia Trials in Baltimore →

Browse More Trials by Condition

Fibromyalgia TrialsOsteogenesis Imperfecta TrialsAll Conditions →

Ready to Join in Baltimore?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Baltimore, MD