NCT07425535 · Johns Hopkins University
Optic Nerve Head Strain in Non-glaucoma Subjects
What this study is about
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
View original scientific description
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
Interventions
DRUG
Latanoprost (0.005%)
Participants take the eye drop daily for less than one month
Primary outcome measures
Optic nerve head strain
Time frame: up to 1 month
Biomechanical strain measured by optical coherence tomography
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adults who have no history of OAG
- Have an ocular examination by a glaucoma specialist with no indications of OAG
- Have normal optical coherence tomography findings in the retinal nerve fiber layer.
- Over age 30 will be included from
- All ethnic groups.
- Optic neuropathy.
- Both suspects and those with glaucoma damage will be included.
- When both eyes meet inclusion and
Exclusion criteria
- , both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual. Exclusion Criteria:
- in whom sitting in an upright position is impossible due to physical disability
- with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
- in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
- who cannot perform home tonometry accurately at certification
- who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
- with any form of glaucoma
- with high myopia defined as refractive error \> -8
- with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
- inability to understand English or with a language or hearing impairment
Where
- Baltimore, Maryland
Collaborators
National Eye Institute (NEI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 13, 2026 · Source of record for eligibility and locations