New Haven, CTNCT06209359Now EnrollingIRB Ready

Heart Failure Clinical Trial in New Haven, CT

Access cutting-edge heart failure treatment through this clinical trial at a research site in New Haven. Study-provided care at no cost to qualified participants.

Sponsored by Yale University

Quick Self-Assessment

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Expert Care in New Haven

Access heart failure specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related heart failure treatment provided free

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Check if you qualify for this heart failure clinical trial in New Haven, CT

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to New Haven

    Convenient for CT residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New Haven site if eligible
  4. 4Begin participation

About This Heart Failure Study in New Haven

Randomized double-blind placebo-controlled crossover study design

Sponsor: Yale University

Who Can Participate

Inclusion Criteria

Clinical diagnosis of heart failure
No plan for titration/change of heart failure medical or device therapies during the study period.
Absence of non-elective hospitalizations in the previous 2 months.
At optimal volume status by symptoms, exam, and dry weight.
Serum potassium ≤ 5.0 mmol/L
Serum sodium ≥ 130 milliequivalents/ liter (mEq/L)
Hemoglobin ≥8 g/dL
Age \>18 years
Objective evidence of diuretic resistance to a 10mg bumetanide challenge (screening visit may occur under this protocol or HIC2000032328 or HIC2000034315) defined as:
FENa \<10% and total sodium output \<150mmol
And at least one of the following criteria:
Chronic home furosemide dose greater than or equal to 80mg furosemide equivalents
eGFR \< 60ml/min
Serum chloride \<100mmol/L
FENa \<5% and total sodium output \<75mmol on the 2 hour

Exclusion Criteria

Glomerular filtration rate (GFR) \<20 ml/min/1.73m2
Use of any non-loop type diuretic in the last 7 days with the exclusion of low dose aldosterone antagonist (e.g., spironolactone ≤50 mg)
History of flash pulmonary edema or a "brittle" volume sensitive HF phenotype such as amyloid cardiomyopathy
Hemoglobin \< 8 g/dL
Pregnant or breastfeeding
Cirrhosis or known liver disease
History of metabolic or respiratory acidosis within 30 days
Use of metformin, acetazolamide, or any other agent that could predispose to acidosis
Patients who are on metformin may be enrolled if their metformin can be safely discontinued for the randomized treatment periods in each arm. Any participants who have consistently elevated blood glucose readings \> 200 mg/dL while inpatient will not be enrolled.
Serum bicarbonate level \<24mmol/L at screening visit
Venous potential of hydrogen(pH) \<7.35 at screening visit
Inability to give written informed consent or comply with study protocol or follow-up visits
On Lithium therapy
On pimozide or thioridazine
Diagnosis of liver failure
Contraindications or allergy to sulfonamides
Any contraindication to thiazide diuretic or allergy to thiazide or bendroflumethiazide

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New Haven?

Yes, this clinical trial (NCT06209359) has an active research site in New Haven, CT that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Heart Failure Treatment Options in New Haven, CT

If you're searching for heart failure treatment options in New Haven, CT, this clinical trial (NCT06209359) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New Haven research site is actively enrolling participants for this clinical trial. You'll receive care from experienced heart failure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all heart failure clinical trials near you to find additional studies recruiting in your area.

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