Chicago, ILNCT06245109Now EnrollingIRB Ready

Knee Osteoarthritis Clinical Trial in Chicago, IL

Access cutting-edge knee osteoarthritis treatment through this phase 4 clinical trial at a research site in Chicago. Study-provided care at no cost to qualified participants.

Sponsored by Northwestern University

Quick Self-Assessment

See if you qualify for this Chicago location

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Expert Care in Chicago

Access knee osteoarthritis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related knee osteoarthritis treatment provided free

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Check if you qualify for this knee osteoarthritis clinical trial in Chicago, IL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Chicago

    Convenient for IL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Chicago site if eligible
  4. 4Begin participation

About This Knee Osteoarthritis Study in Chicago

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have a knee Xray, (optional) MRIs of the brain and knee, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.

Sponsor: Northwestern University

Who Can Participate

Inclusion Criteria

Male or female, age greater than 40 years, with no racial/ethnic restrictions;
Meet American College of Radiology criteria for knee osteoarthritis (OA) based on radiographic evidence;
Knee pain most days of the week for the past month at screening;
Must have average pain score for the week prior to baseline of ≥ 4.0 (on a 0 to 10 Numeric Rating Scale)
Must complete pain ratings on at least 4 out of 7 days prior to baseline;
Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires;
Must be in generally stable health;
Must be able to return for all clinic visits;
Willing to remain stable on any concomitant therapies (Transcutaneous Electrical Nerve Stimulation (TENS) unit, ice, glucosamine chondroitin, cannabinoids, etc.);
Must sign an informed consent document after complete explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate;
Ambulatory with or without a cane, brace(s), or walking stick (use of walker or wheelchair will be

Exclusion Criteria

Glucagon-like peptide 1 (GLP-1) agonists or other weight-loss treatment permitted if started more than 3 months prior to screening with no significant change in weight (+/- 11 lbs) over the past 30 days; Exclusion Criteria:
Evidence of rheumatoid arthritis, ankylosing spondylitis, other inflammatory arthropathy;
Functional class IV congestive heart failure;
Significant other medical disease such as uncontrolled hypertension, untreated diabetes mellitus, coronary or peripheral vascular disease, chronic obstructive lung disease, or liver disease (liver function tests \> upper limit of normal);
Current use of illicit drugs or history (in last 12 months) of alcohol or drug abuse;
Current cannabinoid use for knee pain;
High dose opioid use, as defined as \> 50mg morphine equivalent/day;
Any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk;
In the judgment of the investigator, unable or unwilling to follow protocol and instructions;
Intra-axial implants (e.g., spinal cord stimulators or pumps);
Currently breastfeeding, pregnant, or planning to become pregnant during the study;
Chronic neurologic conditions, e.g., Parkinson's;
Renal insufficiency (creatinine \>1.5 mg/dl);
Previous history of peptic ulcer or gastrointestinal bleeding;
Current use of anticoagulants or platelet inhibitors other than aspirin at ≤325 mg/day;
Allergy to sulfonamide drugs, duloxetine, nonsteroidal anti-inflammatory drugs (NSAIDs), or acetaminophen;
Acute myocardial infarction or coronary artery bypass graft surgery, in the past 12 months;
Recent injection into the index knee of hyaluronic acid or other substance in the last 6 months, or steroid in the last 90 days;
Lactose allergy;
Current use of selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and/or tricyclic antidepressants (TCAs) at a therapeutic dose. Occasional use of these medications as a sleep aid will be allowed; however, participants will need to agree to remain on a stable dose of the medication while in the study;
Uncontrolled narrow-angle glaucoma;
Malignancy within 2 years of screening, with the exception of squamous cell carcinoma, basal cell carcinoma and prostate cancer (grade group 1);
Active treatment for cancer other than superficial skin cancer; or
Nerve ablation performed on the index knee within 12 months of screening.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chicago?

Yes, this clinical trial (NCT06245109) has an active research site in Chicago, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Knee Osteoarthritis Treatment Options in Chicago, IL

If you're searching for knee osteoarthritis treatment options in Chicago, IL, this clinical trial (NCT06245109) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chicago research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced knee osteoarthritis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all knee osteoarthritis clinical trials near you to find additional studies recruiting in your area.

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