NCT06928116 · University of Nebraska
Heat thErapy And mobiLity in COVID-19 Survivors
(HEAL)
What this study is about
Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC.
View original scientific description
Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC. This clinical trial seeks to establish the tolerability and efficacy of at home lower-body heat therapy for improving functional capacity along with metabolic and vascular health in late-middle aged and older adults with PASC, also known as "long COVID".
Interventions
BEHAVIORAL
Heat therapy
At home lower body heat therapy
BEHAVIORAL
Sham Control
Sham Thermoneutral
BEHAVIORAL
Walking
Walking intervention
Primary outcome measures
6 min walking distance
Time frame: 8 weeks
Distance covered during 6 min of walking
Short Physical Performance Battery Test
Time frame: 8 weeks
Test of physical functional capacity
Arterial stiffness
Time frame: 8 weeks
Pulse Wave velocity
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Between the ages of 50 and 90 years
- Free from orthopedic limitations that would prohibit performing leg exercise
- BMI \< 40 kg/m2 and weigh \< 400lbs
- Previously contracted Covid-19 and have persistent symptoms such as a fatigue or decline in physical function, for at least 2 months following SARS-CoV-2 infection
Exclusion criteria
- Unable to give written informed consent
- Women who are pregnant, breastfeeding, or likely to become pregnant within the next 6 months
- Women who are taking hormone therapy
- Claustrophobia
- Orthopedic limitations that would prohibit them from walking
- Currently enrolled in an exercise-based or respiratory muscle rehabilitation program.
Where
- Omaha, Nebraska
Collaborators
National Institute on Aging (NIA)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 23, 2025 · Source of record for eligibility and locations