RECOVER-SLEEP: Platform Protocol
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure tha...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertio...
NE3107 in Adults With Neurological Symptoms of Long COVID
Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in ...
AT1001 for the Treatment of Long COVID
The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in...
Top Cities for Long COVID Clinical Trials
Long COVID clinical trials are recruiting across 20 cities. Here are the cities with the most active studies:
About Long COVID
Long COVID (post-acute sequelae of SARS-CoV-2) refers to symptoms persisting weeks to months after the initial COVID-19 infection. Symptoms can include fatigue, brain fog, breathlessness, and joint pain. Research is actively investigating causes and treatments for this complex condition.
Clinical trials are advancing new treatments for long covid. Currently, 4 studies are recruiting a combined 1,982 participants across the United States. Research is being conducted by 4 organizations including Duke University, Wes Ely, BioVie Inc. and 1 others.
2026 Long COVID Research Landscape
As of March 2026, the long covid clinical trial landscape includes 4 actively recruiting studies across 20 cities in the United States. These studies are collectively seeking 1,982 participants, with an average enrollment target of 496 per study.
Research is being led by 4 different organizations, including Duke University, Wes Ely, BioVie Inc., Massachusetts General Hospital.
Geographically, long covid trials are most concentrated in San Francisco, California (3 trials); Tucson, Arizona (2 trials); Aurora, Colorado (2 trials); Jacksonville, Florida (2 trials); Boston, Massachusetts (2 trials) and 7 other cities.
Featured Long COVID Studies
Highlighted recruiting studies for long covid, selected by enrollment size and research scope.
RECOVER-SLEEP: Platform Protocol
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and allows comparative analysis across the interventions. For example, objectives, measures, and endpoints are generalized in the platform protocol, but inter...
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomarkers of inflammation and viral measures, in participants with Long COVID.
NE3107 in Adults With Neurological Symptoms of Long COVID
Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID including difficulty concentrating or remembering things ("brain fog") and fatigue. Researchers will compare NE3107 to a placebo (a look-alike substance that contains no drug) ...
Frequently Asked Questions About Long COVID Clinical Trials
Are there long covid clinical trials near me?
Yes, there are 4 long covid clinical trials currently recruiting across 20+ cities in the United States, including San Francisco, California; Tucson, Arizona; Aurora, Colorado. Browse the studies above to find one at a location convenient for you.
How do I join a long covid clinical trial?
To join a long covid clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are long covid clinical trials free?
Yes, participation in long covid clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of long covid treatments are being studied?
Current long covid clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 4 research organizations.
Is it safe to participate in long covid clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov