Atlanta, GANCT06580145Now EnrollingIRB Ready

Major Depression Clinical Trial in Atlanta, GA

Access cutting-edge major depression treatment through this clinical trial at a research site in Atlanta. Study-provided care at no cost to qualified participants.

Sponsored by Emory University

Quick Self-Assessment

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Expert Care in Atlanta

Access major depression specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related major depression treatment provided free

Apply for This Atlanta Location

Check if you qualify for this major depression clinical trial in Atlanta, GA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Atlanta

    Convenient for GA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Atlanta site if eligible
  4. 4Begin participation

About This Major Depression Study in Atlanta

The study aims to investigate the effects of a 6-week leucine challenge on brain chemistry, connectivity, and behavior in people with midlife depression. The researchers will compare the leucine and an active comparator arm (lysine) for 6 weeks.

Sponsor: Emory University

Who Can Participate

Inclusion Criteria

Able and willing to provide informed consent
Diagnosis of major depression per Structured Interview for DSM-V (SCID-V)
Moderate to severe depression- Inventory of Depressive Symptoms - Self Reported (IDS-SR score \>34).
SHAPS score \>30 on the 0-56 scale
Body mass index (BMI) between 20-35 kg/m2
Plasma CRP \>1 mg/L
No contraindications to MRI
Availability of friends or family for transportation after lumbar puncture procedure
Clinically significant findings on EKG
Patient Health Questionnaire (PHQ-9) score greater than 10
Willingness to adopt contraceptive measures. Persons exempt from contraception requirements are:
Persons assigned male at birth
Persons assigned female at birth who:
have undergone a hysterectomy or bilateral oophorectomy; or
have been naturally postmenopausal for at least 24 consecutive months (i.e., has NOT had menses at any time in the preceding 24 consecutive months)

Exclusion Criteria

Leucine-Specific:
History of maple syrup urine disease
Risk of hypoglycemia (unstable diabetes)
History of vitamin B6 deficiency, relative
Lysine-Specific:
On calcium supplements, relative
History of renal/gall stones (could cleared by a primary care provider)
Cognitive: --Cognitive impairment (MMSE score \<28)
Psychiatric Disorders:
Lifetime diagnosis of psychotic disorders.
Current mania/hypomania.
Substance use disorder in the last 6 months.
Active suicidal ideation:
Psychiatric hospitalization in the past year.
Suicide attempts within the last five years.
Scores \>3 on the Columbia Suicide Severity Rating Scale (C-SSRS)
Binge eating in the absence of mood symptoms increases.
Primary diagnosis of severe DSM-V79 anxiety disorders.
Primary diagnosis of DSM-V PTSD (if severity exceeds major depression).
Primary diagnosis of DSM-V obsessive-compulsive disorders.
Significant personality disorders with multiple hospitalizations or suicide attempts.
Developmental disorders (e.g., ADHD).
Concomitant medications:
Immune-active medications (e.g., non-steroidal anti-inflammatory agents).
Antibiotics and immunizations in the past 2 weeks.
Topical or inhaled steroids within the past week.
Oral/parenteral steroids in the last 6 months.
Supplements that impact the immune system (e.g., omega-3, probiotics) within the past 2 weeks.
Psychotropic medications within the last 4 weeks (8 weeks for fluoxetine).
Daily use of sedative-hypnotics, benzodiazepines, and opiates.
Medical Disorders:
Unstable medical disorders (frequent provider or medication changes).
Lifetime diagnosis/treatment of cancers (excluding basal cell carcinoma).
Lifetime diagnosis/treatment of autoimmune disorders.
Lifetime exposure to chemotherapeutic agents.
MRI Considerations: \-- Location and quantity of metallic objects safe to MR
Concomitant Treatment for Depression: \-- Treatments with antidepressant medications or those with antidepressant effects (dopamine supplements).
Treatment for General Medical Conditions (GMCs):
Stabilized medications are allowed if maintained at the same dose during the trial.
Multiple recent changes in concomitant medications reviewed by the study PI
Pregnant women.
Individuals unable to consent

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Atlanta?

Yes, this clinical trial (NCT06580145) has an active research site in Atlanta, GA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Major Depression Treatment Options in Atlanta, GA

If you're searching for major depression treatment options in Atlanta, GA, this clinical trial (NCT06580145) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Atlanta research site is actively enrolling participants for this clinical trial. You'll receive care from experienced major depression specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all major depression clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Atlanta, GA