Stony Brook, NYNCT07095205Now EnrollingIRB Ready

Major Depressive Disorder (MDD) Clinical Trial in Stony Brook, NY

Access cutting-edge major depressive disorder (mdd) treatment through this phase 4 clinical trial at a research site in Stony Brook. Study-provided care at no cost to qualified participants.

Sponsored by Stony Brook University

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Expert Care in Stony Brook

Access major depressive disorder (mdd) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related major depressive disorder (mdd) treatment provided free

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Check if you qualify for this major depressive disorder (mdd) clinical trial in Stony Brook, NY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Stony Brook

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Stony Brook site if eligible
  4. 4Begin participation

About This Major Depressive Disorder (MDD) Study in Stony Brook

In the brain, certain nerve cells communicate using a chemical called acetylcholine. Acetylcholine is thought to be important for several functions including mood, memory and wakefulness. The purpose of this study is to explore the role of these nerve cells in depression. Also, we would like to understand how nicotine, the study drug, works in depression and how it affects these nerve cells. To do this, brain imaging will be used before and after this treatment.

Sponsor: Stony Brook University

Who Can Participate

Inclusion Criteria

For Non-Depressed Participants:
Age range 18 to 65 years old.
Capacity to consent (able to read, understand, and sign informed consent). For Participants with MDD
Age range 18 to 65 years old.
Capacity to consent (able to read, understand, and sign informed consent).
Major Depressive Disorder (MDD) as primary diagnosis and currently in a major depressive episode
Score of at least 29 on the Montgomery-Asberg Depression Rating Scale (MADRS).

Exclusion Criteria

For Non-Depressed Participants:
Nicotine use, including tobacco, e-cigarettes, nicotine patch, nicotine gum, within the past year \[except for occasional users, who cannot use nicotine products in the week before the scan\].
Need for use of medication during the study that will affect cholinergic levels.
Problematic drug/alcohol use that is judged sufficient to interfere with study procedures during the treatment period or impact participant safety.
Significant active physical illness or neurological deficit that may affect brain function or imaging.
Significant eye conditions such as keratoconus and/or need for rigid contact lenses.
Current or lifetime history of a major psychiatric diagnosis.
Any MRI contraindications, including recent tattoos, metal implants, pacemaker, metal prostheses, orthodontic appliances, or presence of shrapnel that are contraindicated for MRI.
Any PET contraindications, including if study imaging will result in the participant receiving greater exposure than the research limit, or if participant is pregnant, currently breastfeeding, or planning to conceive during the course of study participation.
Blood donation within 8 weeks of the \[18F\]VAT scan. For Participants with MDD
Nicotine use, including tobacco, e-cigarettes, nicotine patch, nicotine gum, within the past year \[except for occasional users, who cannot use nicotine products in the week before the scan\].
Currently on effective antidepressant medications or need for use of medications that target the cholinergic system.
Problematic drug/alcohol use that is judged sufficient to interfere with study procedures during the treatment period or impact participant safety.
Significant active physical illness or neurological deficit that may affect the brain function or imaging.
Significant eye conditions such as keratoconus and/or need for rigid contact lenses.
Current or lifetime major psychiatric diagnosis other than MDD.
Life-time history of psychosis or current psychosis.
Significant risk for suicide.
Any MRI contraindications, including recent tattoos, metal implants, pacemaker, metal prostheses, orthodontic appliances, or presence of shrapnel that are contraindicated for MRI.
Any PET contraindications, including if study imaging will result in the participant receiving greater exposure than the research limit, or if participant is pregnant, currently breastfeeding, or planning to conceive during the course of study participation.
Blood donation within 8 weeks of the \[18F\]VAT scan.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Stony Brook?

Yes, this clinical trial (NCT07095205) has an active research site in Stony Brook, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Major Depressive Disorder (MDD) Treatment Options in Stony Brook, NY

If you're searching for major depressive disorder (mdd) treatment options in Stony Brook, NY, this clinical trial (NCT07095205) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Stony Brook research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced major depressive disorder (mdd) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all major depressive disorder (mdd) clinical trials near you to find additional studies recruiting in your area.

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