Belmont, MANCT05630963Now EnrollingIRB Ready

Major Depressive Disorder Clinical Trial in Belmont, MA

Access cutting-edge major depressive disorder treatment through this clinical trial at a research site in Belmont. Study-provided care at no cost to qualified participants.

Sponsored by Mclean Hospital

Quick Self-Assessment

See if you qualify for this Belmont location

Preparing your pre-screening questions…

Expert Care in Belmont

Access major depressive disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related major depressive disorder treatment provided free

Apply for This Belmont Location

Check if you qualify for this major depressive disorder clinical trial in Belmont, MA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Belmont

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Belmont site if eligible
  4. 4Begin participation

About This Major Depressive Disorder Study in Belmont

This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD). It also examines how individuals with a history of depression make certain decisions and which brain regions are involved in such decisions. Information collected through MRI, PET, biospecimens (i.e., blood, saliva) and behavioral tasks will be used to predict depressive symptoms in the future.

Sponsor: Mclean Hospital

Who Can Participate

Inclusion Criteria

for all participants:
All genders, races, and ethnic origins, aged between 18 and 45
Capable of providing written informed consent, and fluent in English
Right-handed
Absence of any psychotropic medications for at least 2 weeks
Has a smartphone (iPhone or Android) (needed for Ecological Momentary Assessment) Inclusion Criteria for "Remitted MDD" group:
Meets inclusion criteria for all subjects, plus:
History of MDD as defined by DSM-5
Absence of anxiety disorder for the past two months Inclusion Criteria for "Current MDD" group:
Meets inclusion criteria for all subjects, plus:
Presence of MDD as defined by DSM-5
Absence of anxiety disorder for the past two months

Exclusion Criteria

for all participants:
Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician. These patients will be immediately referred to appropriate clinical treatment
Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, or partner with vasectomy)
Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
History of seizure disorder
History of psychiatric illnesses, other than depression or anxiety disorders among the Current MDD and Remitted MDD groups
History of substance use disorder or alcohol use disorder (as these terms are defined by DSM-5); except depressed subjects may have a history of 'Mild' substance/alcohol use disorder only if it ended as least 12 months ago
History of cocaine or stimulant use or dopaminergic drugs
History or current diagnosis of dementia, or a score of \< 26 on the Mini Mental State Examination at the screening visit;
Patients with mood congruent or mood incongruent psychotic features
Current use of other psychotropic drugs
Clinical or laboratory evidence of hypothyroidism
Patients with a lifetime history of electroconvulsive therapy (ECT)
Failure to meet standard MRI safety requirements
Abnormal ECG and lab results
History of seizure disorder
Contraindications for arterial line (e.g., abnormal result on Allen test, Raynaud's syndrome, history of anemia or bleeding disorder, history of fainting from blood draws).

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Belmont?

Yes, this clinical trial (NCT05630963) has an active research site in Belmont, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Major Depressive Disorder Treatment Options in Belmont, MA

If you're searching for major depressive disorder treatment options in Belmont, MA, this clinical trial (NCT05630963) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Belmont research site is actively enrolling participants for this clinical trial. You'll receive care from experienced major depressive disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all major depressive disorder clinical trials near you to find additional studies recruiting in your area.

More Depression Trials in Belmont, MA

See all depression clinical trials recruiting in Belmont — not just this study.

Browse Depression Trials in Belmont →

Browse More Trials by Condition

Depression TrialsMajor Depressive Disorder TrialsAll Conditions →

Ready to Join in Belmont?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Belmont, MA