Is NCT04788524 recruiting in Belmont, MA?

Yes, NCT04788524 is currently recruiting participants at its Belmont, MA location. This major depressive disorder clinical trial is actively enrolling qualified participants.

How do I join the major depressive disorder clinical trial in Belmont?

To join this clinical trial in Belmont, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Belmont clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Major Depressive Disorder Clinical Trial in Belmont, MA

About This Major Depressive Disorder Study in Belmont

Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Sponsor: Mclean Hospital

Who Can Participate

Inclusion Criteria

Females of all ethnic origins See Section: Inclusion of Women and Minorities);

Ages 14-18 (See Section: Inclusion of Children);

Written informed assent/consent from adolescent and parent/guardian (if under age 18);

English as a first language or English fluency;

Right handed111;

Personal cell-phone (for Ecological Momentary Assessment \[EMA\]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session Inclusion Criteria: MDD Sample

Meet Diagnostic Statistical Manual-5th edition (DSM-5) diagnostic criteria for major depressive disorder (as diagnosed with the KSADS)

Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants); Inclusion Criteria: Healthy Control (HC) Sample

No history or current diagnosis of any DSM-5 psychiatric or substance/alcohol-related disorder (as diagnosed with the KSADS)

No first-degree relatives with a history of depression, bipolar disorder, or psychosis

Exclusion Criteria

History of head trauma with loss of consciousness;

History of seizure disorder;

Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease;

History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine);

History of use of dopaminergic drugs (including methylphenidate);

Use of hormonal replacement therapy, anabolic steroids, or hormonal contraception;

Clinical or laboratory evidence of hypothyroidism;

Systemic medical or neurological illness that could impact fMRI measures of cerebral blood flow;

Failure to meet standard exclusion criteria for fMRI scanning (e.g., claustrophobia, cardiac pacemakers, neural pacemakers, surgically implanted metal devices, cochlear implants, metal braces, or other metal objects in the body);

Testing positive on a drug test on the day of the scan which testis for stimulants, marijuana, barbiturates, benzodiazepine, buprenorphine, 3,4-Methyl enedioxy methamphetamine (MDMA), methadone, opiates, oxycodone, phencyclidine;

History of electroconvulsive therapy

Participants with suicidal ideation where study participation is deemed unsafe by the study clinician; Additional Exclusion Criteria: Major Depressive Disorder (MDD) Sample 1\. Major depressive disorder diagnosis secondary to another disorder (selected comorbid anxiety disorders such as generalized anxiety disorder, specific phobia, and social anxiety disorders are allowed if they are secondary to MDD)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Belmont?

Yes, this clinical trial (NCT04788524) has an active research site in Belmont, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Major Depressive Disorder Treatment Options in Belmont, MA

If you're searching for major depressive disorder treatment options in Belmont, MA, this clinical trial (NCT04788524) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Belmont research site is actively enrolling participants for this clinical trial. You'll receive care from experienced major depressive disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all major depressive disorder clinical trials near you to find additional studies recruiting in your area.

Major Depressive Disorder Clinical Trial in Belmont, MA

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